Prevalence, outcome, and management of risk factors in patients with breast cancer with peripheral arterial disease: A tertiary cancer center's experience Journal Article
| Authors: | Bryce, Y.; Bourguillon, R.; Camacho Vazquez, J.; Ziv, E.; Kim, D.; Santos Martin, E. |
| Article Title: | Prevalence, outcome, and management of risk factors in patients with breast cancer with peripheral arterial disease: A tertiary cancer center's experience |
| Abstract: | Introduction: The risk factors of breast cancer overlap with those of peripheral arterial disease (PAD), with increasing prevalence. In addition, there is under-utilization of risk factor modification measures in patients with PAD. Materials and Methods: Electronic medical records of patients with breast cancer with International Classification of Diseases 9/10 codes for PAD spanning 10 years from June 1, 2009 to June 1, 2019 were reviewed. Results: A total of 248 patients, 98% women, with a median age of 75 years and with a median follow-up of 76 months, were included. PAD risk factors were identified as smoking (44%), obesity (38%), hyperlipidemia (68%), hypertension (HTN) (74%), and diabetes (42%). Overall, survival was significantly impacted by smoking (P =.0301) and HTN (P =.0052). In a Cox proportion hazard ratio regression, HTN (overall death hazard ratio [HR], 3.1784; 95% CI, 1.0291-6.7490; P =.0070; cancer-related death HR, 2.6354; 95% confidence interval [CI], 1.0291-6.7490; P =.0434) and smoking (overall death HR, 1.7452; 95% CI 1.0707-2.8444; P =.0255; cancer-related death HR, 2.7432; 95% CI, 1.4190-5.3030; P =.0027) were predictors of overall death and cancer-related death. Of all patients, 48% were on statins and 54% were on antiplatelet therapies. Of the patients, 62% of current smokers were offered a smoking cessation program, 27% of obese patients were offered a nutrition consult, 42% of patients with diabetes had blood glucose controlled, and 54% of patients with HTN had blood pressure controlled. Conclusion: Smoking and HTN are risk factors associated with decreased survival and predictive of overall death and cancer-related death. In this population, risk factor modification was under-utilized. © 2021 Elsevier Inc. |
| Keywords: | cancer survival; controlled study; aged; human cell; major clinical study; overall survival; cancer risk; hypertension; cancer patient; follow up; breast cancer; prevalence; risk factors; obesity; smoking; anticoagulant therapy; retrospective study; cancer mortality; cause of death; diabetes mellitus; glucose; hydroxymethylglutaryl coenzyme a reductase inhibitor; hyperlipidemia; antithrombocytic agent; risk management; clinical outcome; blood pressure regulation; smoking cessation program; peripheral occlusive artery disease; peripheral arterial disease; human; male; female; article; blood glucose monitoring; obese patient; current smoker; risk factor modification |
| Journal Title: | Clinical Breast Cancer |
| Volume: | 21 |
| Issue: | 4 |
| ISSN: | 1526-8209 |
| Publisher: | Elsevier Inc. |
| Date Published: | 2021-08-01 |
| Start Page: | 337 |
| End Page: | 343 |
| Language: | English |
| DOI: | 10.1016/j.clbc.2020.12.010 |
| PUBMED: | 33487579 |
| PROVIDER: | scopus |
| PMCID: | PMC9447485 |
| DOI/URL: | |
| Notes: | Article -- Export Date: 1 October 2021 -- Source: Scopus |
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