Allergies, obesity, other risk factors and survival from pancreatic cancer Journal Article


Authors: Olson, S. H.; Chou, J. F.; Ludwig, E.; O'reilly, E.; Allen, P. J.; Jarnagin, W. R.; Bayuga, S. J.; Simon, J.; Gonen, M.; Reisacher, W. R.; Kurtz, R. C.
Article Title: Allergies, obesity, other risk factors and survival from pancreatic cancer
Abstract: Survival from pancreatic adenocarcinoma remains extremely poor, approximately 5% at 5 years. Risk factors include smoking, high body mass index (BMI), family history of pancreatic cancer, and long-standing diabetes; in contrast, allergies are associated with reduced risk. Little is known about associations between these factors and survival. We analyzed overall survival in relation to risk factors for 475 incident cases who took part in a hospital based case-control study. Analyses were conducted separately for those who did (160) and did not (315) undergo tumor resection. Kaplan-Meier methods were used to describe survival according to smoking, BMI, family history, diabetes, and presence of allergies. Cox proportional hazards models were used to adjust for covariates. There was no association with survival based on smoking, family history, or history of diabetes in either group. Among patients with resection, those with allergies showed nonstatistically significant longer survival, a median of 33.1 months (95% CI: 19.0-52.5) vs. 21.8 months (95% CI: 18.0-33.1), p = 0.25. The adjusted hazard ratio (HR) was 0.72 (95% CI: 0.43-1.23), p = 0.23. Among patients without resection, those with self-reported allergies survived significantly longer than those without allergies: 13.3 months (95% CI: 10.6-16.9) compared to 10.4 months (95% CI: 8.8-11.0), p = 0.04, with an adjusted HR of 0.68 (95% CI: 0.49-0.95), p = 0.02. Obesity was nonsignificantly associated with poorer survival, particularly in the resected group (HR = 1.62, 95% CI: 0.76-3.44). The mechanisms underlying the association between history of allergies and improved survival are unknown. These novel results need to be confirmed in other studies. © 2010 UICC.
Keywords: survival; adult; cancer survival; controlled study; aged; middle aged; survival rate; major clinical study; overall survival; case control study; case-control studies; united states; pancreas cancer; pancreatic neoplasms; cancer staging; neoplasm staging; adenocarcinoma; disease association; family health; allergy; risk factors; obesity; smoking; pathology; risk factor; self report; carcinogenesis; survival time; body mass; family history; diabetes mellitus; pancreas tumor; disease duration; pancreatic cancer; hypersensitivity; allergies; bmi; hospital based case control study; pancreas surgery
Journal Title: International Journal of Cancer
Volume: 127
Issue: 10
ISSN: 0020-7136
Publisher: John Wiley & Sons  
Date Published: 2010-11-15
Start Page: 2412
End Page: 2419
Language: English
DOI: 10.1002/ijc.25240
PUBMED: 20143395
PROVIDER: scopus
DOI/URL:
Notes: --- - "Export Date: 20 April 2011" - "CODEN: IJCNA" - "Source: Scopus"
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MSK Authors
  1. Joanne Fu-Lou Chou
    153 Chou
  2. Sara H Olson
    208 Olson
  3. Mithat Gonen
    701 Gonen
  4. Emmy Ludwig
    45 Ludwig
  5. Peter Allen
    436 Allen
  6. William R Jarnagin
    583 Jarnagin
  7. Eileen O'Reilly
    316 O'Reilly
  8. Robert C Kurtz
    132 Kurtz
  9. Jennifer Anne Simon
    11 Simon