Skin cancers and their etiologies Journal Article
| Author: | Marghoob, A. A. |
| Article Title: | Skin cancers and their etiologies |
| Abstract: | Skin cancers are the most common form of malignancy. Early diagnosis and treatment provides the best chance for survival and reduced morbidity. However, some patients have recurrent or resistant lesions. In patients with basal cell carcinoma (BCC), prognosis is relatively good for all four types of lesions (superficial, nodular, infiltrative, and morpheaform), but the highest recurrence rates and greatest morbidity are associated with infiltrative and morpheaform BCC, and prognosis is least favorable when perineural invasion has occurred. Research into the etiology of BCC and other skin cancers has led to the identification of several genetic mutations-those of the Patched and Hedgehog genes. By targeting these pathways, treatments aimed at driver mutations hold promise for new nonsurgical treatments. © 2011 Elsevier Inc. |
| Keywords: | cancer surgery; gene mutation; cancer recurrence; cancer diagnosis; basal cell carcinoma; skin neoplasms; morbidity; sonic hedgehog protein; hedgehog proteins; skin cancer; cancer invasion; medical research; cancer infiltration; targeted therapy; perineurium; ultraviolet rays; carcinoma, basal cell; basal cell nevus syndrome; genes, p53; receptors, cell surface |
| Journal Title: | Seminars in Cutaneous Medicine and Surgery |
| Volume: | 30 |
| Issue: | 4 Suppl. |
| ISSN: | 1085-5629 |
| Publisher: | W.B. Saunders Co-Elsevier Inc. |
| Date Published: | 2011-12-01 |
| Start Page: | S1 |
| End Page: | S5 |
| Language: | English |
| DOI: | 10.1016/j.sder.2011.11.003 |
| PROVIDER: | scopus |
| PUBMED: | 22177100 |
| DOI/URL: | |
| Notes: | --- - "Export Date: 1 February 2012" - "CODEN: SCMSF" - "Source: Scopus" |
