Non-enzymatic covalent modifications as a new chapter in the histone code Review

   


Authors: Maksimovic, I.; David, Y.
Review Title: Non-enzymatic covalent modifications as a new chapter in the histone code
Abstract: The interior of the cell abounds with reactive species that can accumulate as non-enzymatic covalent modifications (NECMs) on biological macromolecules. These adducts interfere with many cellular processes, for example, by altering proteins’ surface topology, enzymatic activity, or interactomes. Here, we discuss dynamic NECMs on chromatin, which serves as the cellular blueprint. We first outline the chemistry of NECM formation and then focus on the recently identified effects of their accumulation on chromatin structure and transcriptional output. We next describe the known cellular regulatory mechanisms that prevent or reverse NECM formation. Finally, we discuss recently developed chemical biology platforms for probing and manipulating these NECMs in vitro and in vivo. © 2021 Elsevier Ltd
Keywords: controlled study; review; genetic transcription; in vivo study; in vitro study; regulatory mechanism; epigenetics; chromatin; chromatin structure; acylation; covalent bond; chemical biology; lipidation; histone code; glycation
Journal Title: Trends in Biochemical Sciences
Volume: 46
Issue: 9
ISSN: 0968-0004
Publisher: Elsevier Inc.  
Date Published: 2021-09-01
Start Page: 718
End Page: 730
Language: English
DOI: 10.1016/j.tibs.2021.04.004
PUBMED: 33965314
PROVIDER: scopus
PMCID: PMC8364488
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-85105263563&doi=10.1016%2fj.tibs.2021.04.004&partnerID=40&md5=12c7ee76702c54a14c5f8ed83601612e
Notes: Review -- Export Date: 1 September 2021 -- Source: Scopus
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MSK Authors
  1. Yael Ema David Shternberg
    45 David Shternberg
  2. Igor Maksimovic
    9 Maksimovic
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