Depth of invasion versus tumour thickness in early oral tongue squamous cell carcinoma: Which measurement is the most practical and predictive of outcome? Journal Article

   

Authors:	Salama, A. M.; Valero, C.; Katabi, N.; Khimraj, A.; Yuan, A.; Zanoni, D. K.; Ganly, I.; Patel, S. G.; Ghossein, R.; Xu, B.
Article Title:	Depth of invasion versus tumour thickness in early oral tongue squamous cell carcinoma: Which measurement is the most practical and predictive of outcome?
Abstract:	Aims: The 8th edition of the American Joint Committee on Cancer (AJCC) Staging introduced depth of invasion (DOI) into the pT category of oral cavity squamous cell carcinoma. However, we noted multiple practical obstacles in accurately measuring DOI histologically in our daily practice. Methods and results: To compare the prognostic effects of DOI and tumour thickness (TT), a meticulous pathology review was conducted in a retrospective cohort of 293 patients with AJCC 7th edition pT1/T2 oral tongue squamous cell carcinoma. Overall survival (OS) and nodal metastasis rate at initial resection were the primary and secondary outcomes, respectively. We found that TT and DOI were highly correlated with a correlation coefficient of 0.984. The upstage rate was only 6% (18 of 293 patients) when using TT in the pT stage compared with using DOI. More importantly, DOI and TT, as well as pT stage using DOI and pT stage using TT, performed identically in predicting risk of nodal metastasis and OS. Conclusions: We therefore propose to replace DOI, a complicated measurement with many challenges, with TT in the pT staging system. © 2020 John Wiley & Sons Ltd
Keywords:	ajcc staging; depth of invasion; prognosis; oral tongue squamous cell carcinoma; tumour thickness
Journal Title:	Histopathology
Volume:	79
Issue:	3
ISSN:	0309-0167
Publisher:	Wiley Blackwell
Date Published:	2021-09-01
Start Page:	325
End Page:	337
Language:	English
DOI:	10.1111/his.14291
PUBMED:	33112422
PROVIDER:	scopus
PMCID:	PMC8079561
DOI/URL:	https://www.scopus.com/inward/record.uri?eid=2-s2.0-85097509693&doi=10.1111%2fhis.14291&partnerID=40&md5=48f35c00fec077824d9a437c75bdd6cd
Notes:	Article -- Export Date: 1 September 2021 -- Source: Scopus

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