Intravenous treatment of autoimmune hemolytic anemia with very high dose gammaglobulin Journal Article
| Authors: | Bussel, J. B.; Cunningham‐Rundles, C.; Abraham, C. |
| Article Title: | Intravenous treatment of autoimmune hemolytic anemia with very high dose gammaglobulin |
| Abstract: | Abstract. Autoimmune hemolytic anemia (AIHA) has been considered to be unresponsive to intravenous gammaglobulin (IVGG) at the doses that are effective in immune thrombocytopenic purpura and autoimmune neutropenia (usually 2 g/kg total dose). This study reports the use of a higher dose (5 g/kg total dose over 5 days) in four severe cases of AIHA which resulted in a sustained remission in two patients, a transient response in the third, and a failure in the forth patient. These data suggest that larger quantities of IVGG may be needed in this disease, possibly because the reticuloendothelial system appears to be enlarged in AIHA patients. © 1986 S. Karger AG, Basel |
| Keywords: | adult; clinical article; child, preschool; unclassified drug; prednisone; immunoglobulin; immunotherapy; immunoglobulin g; infant; azathioprine; autoimmune hemolytic anemia; drug dose; phagocytosis; therapy; intravenous drug administration; injections, intravenous; reticuloendothelial system; dose-response relationship, immunologic; human; male; female; priority journal; support, non-u.s. gov't; anemia, hemolytic, autoimmune; gamma-globulins; blood and hemopoietic system; endoglobulin |
| Journal Title: | Vox Sanguinis |
| Volume: | 51 |
| Issue: | 4 |
| ISSN: | 0042-9007 |
| Publisher: | Blackwell Publishing |
| Date Published: | 1986-12-01 |
| Start Page: | 264 |
| End Page: | 269 |
| Language: | English |
| DOI: | 10.1111/j.1423-0410.1986.tb01967.x |
| PUBMED: | 2432727 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Article -- Export Date: 18 August 2021 -- Source: Scopus |
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