Structural heterogeneity and functional domains of murine immunoglobulin G Fc receptors Journal Article
| Authors: | Ravetch, J. V.; Luster, A. D.; Weinshank, R.; Kochan, J.; Pavlovec, A.; Portnoy, D. A.; Hulmes, J.; Pan, Y. C. E.; Unkeless, J. C. |
| Article Title: | Structural heterogeneity and functional domains of murine immunoglobulin G Fc receptors |
| Abstract: | Binding of antibodies to effector cells by way of receptors to their constant regions (Fc receptors) is central to the pathway that leads to clearance ofantigens by the immune system. The structure and function ofthis important class of receptors on immune cells is addressed through the molecular characterization of Fc receptors (FcR) specific for the murine immunoglobulin G isotype. Structural diversity is encoded by two genes that by alternative splicing result in expression of molecules with highly conserved extracellular domains and different transmembrane and intracytoplasmic domains. The proteins encoded by these genes are members ofthe immunoglobulin supergene family, most homologous to the major histocompatibility complex molecule Eβ. Functional reconstitution of ligand binding by transfection of individual FcR genes demonstrates that the requirements for ligand bindig are encoded in a single gene. These studies demonstrate the molecular basis for the functional heterogeneity of FcR's, accounting for the possible transduction of different signals in response to a single ligand. |
| Keywords: | nonhuman; protein conformation; animal cell; mouse; animals; mice; heredity; biological model; membrane proteins; transcription, genetic; in vitro study; transfection; structure activity relation; histology; animalia; gene expression regulation; dna; amino acid sequence; immunoglobulin g; genetic engineering; murinae; base sequence; fc receptor; receptors, igg; chemical structure; protein structure; macrophages; histocompatibility antigens class ii; lymphocytes; protein polymorphism; receptors, fc; priority journal |
| Journal Title: | Science |
| Volume: | 234 |
| Issue: | 4777 |
| ISSN: | 0036-8075 |
| Publisher: | American Association for the Advancement of Science |
| Date Published: | 1986-11-07 |
| Start Page: | 718 |
| End Page: | 725 |
| Language: | English |
| DOI: | 10.1126/science.2946078 |
| PUBMED: | 2946078 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Article -- Export Date: 18 August 2021 -- Source: Scopus |
