Pluripoietin α: A second human hematopoietic colony-stimulating factor produced by the human bladder carcinoma cell line 5637 Journal Article

   


Authors: Gabrilove, J. L.; Welte, K.; Harris, P.; Platzer, E.; Lu, L.; Levi, E.; Mertelsmann, R.; Moore, M. A.
Article Title: Pluripoietin α: A second human hematopoietic colony-stimulating factor produced by the human bladder carcinoma cell line 5637
Abstract: We have identified a factor constitutively produced by the human bladder carcinoma cell line 5637, which has the following capacities; (i) to induce the differentiation of the human promyelocytic leukemic cell line HL-60; (ii) to induce the expression of chemotactic peptide receptors in leukemic cells as well as in normal peripheral blood granulocytes; (iii) to function as a chemoattractant for neutrophils as well as, under certain conditions, inhibiting their migration; (iv) to support the growth of eosinophil and granulocyte/macrophage progenitors, which is maximal when scored at day 14; and (v) to support the growth of human mixed pluripotent progenitors and erythroid bursts from normal human bone marrow. This factor has a molecular size of 32 kDa by gel filtration and 16.5 kDa by NaDodSO4/PAGE. We have termed this factor pluripoietin α.
Keywords: unclassified drug; human cell; cell line; cell differentiation; in vitro study; hematopoiesis; high performance liquid chromatography; bladder carcinoma; chemoattractant; colony forming unit gm; bladder; colony stimulating factor; human; priority journal; article; blood and hemopoietic system; pluripoietin alpha
Journal Title: Proceedings of the National Academy of Sciences of the United States of America
Volume: 83
Issue: 8
ISSN: 0027-8424
Publisher: National Academy of Sciences  
Date Published: 1986-04-01
Start Page: 2478
End Page: 2482
Language: English
DOI: 10.1073/pnas.83.8.2478
PROVIDER: scopus
PMCID: PMC323321
PUBMED: 3458209
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-0022551906&doi=10.1073%2fpnas.83.8.2478&partnerID=40&md5=3801f432a25def7caf3a39ddbd957b32
Notes: Article -- Export Date: 18 August 2021 -- Source: Scopus
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MSK Authors
  1. Malcolm A S Moore
    549 Moore
  2. Janice Gabrilove
    122 Gabrilove
  3. Ester Levi
    17 Levi
  4. Karl Welte
    77 Welte
  5. Roland Mertelsmann
    32 Mertelsmann
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