C1 esterase inhibitor deficiency in X-linked hypogammaglobulinaemia: An anomaly fostering anaphylactoid reactions following intramuscular gammaglobulin administration Journal Article
| Authors: | Pollack, S.; Cunningham-Rundles, C.; Good, R. A.; Day, N. K. |
| Article Title: | C1 esterase inhibitor deficiency in X-linked hypogammaglobulinaemia: An anomaly fostering anaphylactoid reactions following intramuscular gammaglobulin administration |
| Abstract: | A patient with apparent X-linked agammaglobulinaemia was found to be inordinately susceptible to anaphylactoid reactions to intramuscular injections of gammaglobulin. The patient was found also to have low levels of Cl esterase inhibitor (Cl INH). The possibility that the Cl INH deficiency in this patient, whether genetic or acquired, fostered the susceptibility to the production of anaphylactoid reactions after gammaglobulin injections urges further studies of the association ofCl INH deficiency and anaphylactoid reactions to gammaglobulin injections. The possibility that Cl INH levels like Clq levels may be low in hypogammaglobulinaemic patients as a consequence of increased catabolism of this regulator of the complement system when IgG levels are low is considered. © The Fellowship of Postgraduate Medicine, 1986. |
| Keywords: | adult; case report; immunoglobulin; x chromosome; drug therapy; anaphylaxis; adverse drug reaction; therapy; linkage (genetics); complement; intramuscular drug administration; injections, intramuscular; immunization, passive; hypogammaglobulinemia; human; male; priority journal; complement component c1s inhibitor; agammaglobulinemia; support, non-u.s. gov't; support, u.s. gov't, p.h.s.; gamma-globulins; complement deficiency; congenital disorder; complement 1 inactivators |
| Journal Title: | Postgraduate Medical Journal |
| Volume: | 62 |
| Issue: | 732 |
| ISSN: | 0032-5473 |
| Publisher: | BMJ Publishing Group Ltd. |
| Date Published: | 1986-10-01 |
| Start Page: | 939 |
| End Page: | 942 |
| Language: | English |
| DOI: | 10.1136/pgmj.62.732.939 |
| PUBMED: | 2430274 |
| PROVIDER: | scopus |
| PMCID: | PMC2419044 |
| DOI/URL: | |
| Notes: | Article -- Export Date: 18 August 2021 -- Source: Scopus |
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