Oncolytic vaccinia virus therapy of salivary gland carcinoma Journal Article
| Authors: | Chernichenko, N.; Linkov, G.; Li, P.; Bakst, R. L.; Chen, C. H.; He, S.; Yu, Y. A.; Chen, N. G.; Szalay, A. A.; Fong, Y.; Wong, R. J. |
| Article Title: | Oncolytic vaccinia virus therapy of salivary gland carcinoma |
| Abstract: | Objective: To examine the therapeutic effects of an attenuated, replication-competent vaccinia virus (GLV-1h68) against a panel of 5 human salivary gland carcinoma cell lines. Design: The susceptibility of 5 salivary gland carcinoma cell lines to infection and oncolysis by GLV-1h68 was assessed in vitro and in vivo. Results: All 5 cell lines were susceptible to viral infection, transgene expression, and cytotoxic reactions. Three cell lines were exquisitely sensitive to infection by very low doses of GLV-1h68. Orthotopic parotid tumors exhibited more aggressive behavior compared with flank tumors. A single intratumoral injection of GLV-1h68 induced significant tumor regression without observed toxic effects in flank and parotid tumor models; controls demonstrated rapid tumor progression. Conclusion: These promising results demonstrate significant oncolytic activity by an attenuated vaccinia virus for infecting and lysing salivary gland carcinomas, supporting future clinical trials. © 2013 American Medical Association. All rights reserved. |
| Keywords: | unclassified drug; human cell; nonhuman; mouse; animal tissue; gene expression; green fluorescent protein; luciferase; animal experiment; in vivo study; cancer cell culture; cytotoxicity; in vitro study; enzyme activity; cancer regression; human cell culture; xenograft; cancer size; beta galactosidase; oncolytic virus; oncolytic virotherapy; vaccinia virus; glv 1h68; virus replication; salivary gland carcinoma; infection sensitivity |
| Journal Title: | JAMA Otolaryngology - Head and Neck Surgery |
| Volume: | 139 |
| Issue: | 2 |
| ISSN: | 2168-6181 |
| Publisher: | American Medical Association |
| Date Published: | 2013-02-01 |
| Start Page: | 173 |
| End Page: | 182 |
| Language: | English |
| PROVIDER: | scopus |
| PUBMED: | 23429949 |
| DOI: | 10.1001/jamaoto.2013.1360 |
| PMCID: | PMC4413455 |
| DOI/URL: | |
| Notes: | --- - "Export Date: 1 May 2013" - ":doi 10.1001/jamaoto.2013.1360" - "Source: Scopus" |
Altmetric
Citation Impact
BMJ Impact Analytics
Related MSK Work