| Abstract: |
To better study the interaction between tumors and the immune system, scientists have attempted to create humanized mice in which certain types of hematopoietic cells are replaced with human cells. Such mice have found applications not only in cancer research but also in the study of infectious and immune-mediated diseases. This chapter focuses on immunodeficient mice that are commonly used in preclinical biomedical research. In immunodeficient mouse models, the engraftment of human T cells through xenotransplantation of primary tumor samples patient-derived xenografts containing cotransplanted human lymphoid cells, hematopoietic stem cells and human peripheral-blood mononuclear cells to create humanized mice can give rise to the human-into-mouse xenogeneic graft-versus-host disease. Transmission studies indicated that a pan T-cell deficiency was needed for mice to develop lesions; however, strain susceptibility differences possibly due to differences in natural killer cell levels between the different immunodeficient strains also constitute underlying contributing factors. © 2022 John Wiley & Sons, Inc. |
