Use of humanized severe combined immunodeficient mice for human vaccine development Journal Article
| Authors: | Koo, G. C.; Hasan, A.; O'Reilly, R. J. |
| Article Title: | Use of humanized severe combined immunodeficient mice for human vaccine development |
| Abstract: | The severe combined immunodeficient (SCID) mouse has no adaptive immunity, lacking mature T and B cells in the peripheral blood or the lymphoid organs. It has been used extensively in biomedical research as a valuable translational model for xeno-engraftment of human tissues and cells. This review focuses on the engraftment of human peripheral blood cells and tissues in SCID mice, as well as in the newly established and more permissive SCID mice deficient in the IL-2 receptor γ-chain. Human immune responses could be elicited and assessed in these humanized SCID mice upon vaccination or sensitization with allogeneic tissues. A translational model is proposed to attain preclinical data for testing human vaccines. © 2009 Expert Reviews Ltd. |
| Keywords: | review; nonhuman; mouse; animals; mice; mice, scid; models, animal; xenograft; vaccination; research; blood cell; tumor cell vaccine; vaccine production; scid mouse; vaccine; preclinical model; severe combined immunodeficient mice; vaccine development; interleukin 2 receptor gamma; peripheral blood mononuclear cell; sensitization; vaccines |
| Journal Title: | Expert Review of Vaccines |
| Volume: | 8 |
| Issue: | 1 |
| ISSN: | 1476-0584 |
| Publisher: | Informa Healthcare |
| Date Published: | 2009-01-01 |
| Start Page: | 113 |
| End Page: | 120 |
| Language: | English |
| DOI: | 10.1586/14760584.8.1.113 |
| PUBMED: | 19093778 |
| PROVIDER: | scopus |
| PMCID: | PMC2677709 |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 3" - "Export Date: 30 November 2010" - "CODEN: ERVXA" - "Source: Scopus" |
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