Hepatic encephalopathy - To the editor Journal Article
| Author: | Vanamee, P. |
| Article Title: | Hepatic encephalopathy - To the editor |
| Abstract: | To the Editor: The Medical Progress article on hepatic encephalopathy by Fraser and Arieff (Oct. 3 issue)1 contains several errors that could lead to mistakes of understanding or treatment. It states, “After ammonia is generated [in the gut], it is transported through the portal circulation to the liver, where it is normally converted to urea.” However, 30 to 40 percent of ammonia is also converted to glutamine in the liver.2 The authors imply that an increased cerebral catabolism of amino acids results in elevated ammonia concentrations in the hyperammonemic brain. The five cited references are inappropriate. The best evidence suggests... © 1986, Massachusetts Medical Society. All rights reserved. |
| Keywords: | hepatic encephalopathy; liver cirrhosis; editorial; central nervous system; liver; brain; gamma-aminobutyric acid; nervous system; ammonia; ammonia blood level; humans; human; priority journal |
| Journal Title: | New England Journal of Medicine |
| Volume: | 314 |
| Issue: | 12 |
| ISSN: | 0028-4793 |
| Publisher: | Massachusetts Medical Society |
| Date Published: | 1986-03-20 |
| Start Page: | 786 |
| Language: | English |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Letter -- Part of a chain of letters, see PMID: 3951510, DOI: 10.1056/nejm198603203141215 -- Export Date: 18 August 2021 -- Source: Scopus |
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