Circulating thymulin and thymosin-α(1) activity in pediatric acquired immune deficiency syndrome: In vivo and in vitro studies Journal Article
| Authors: | Rubinstein, A.; Novick, B. E.; Sicklick, M. J.; Bernstein, L. J.; Incefy, G. S.; Naylor, P. H.; Goldstein, A. L. |
| Article Title: | Circulating thymulin and thymosin-α(1) activity in pediatric acquired immune deficiency syndrome: In vivo and in vitro studies |
| Abstract: | Twenty-five children with acquired immune deficiency syndrome (AIDS) or AIDS-related complex had a characteristic pattern of T cell deficiency. Abnormally low plasma thymulin levels preceded the development of peripheral blood T cell abnormalities. In contrast to patients with congenital T cell deficiencies, our patients had elevated serum levels of thymosin-α1. Treatment with thymosin fraction 5 in three children with AIDS resulted in only transient clinical and immunologic improvement. © 1986 The C. V. Mosby Company. |
| Keywords: | child; clinical article; child, preschool; human cell; drug efficacy; t lymphocyte; t-lymphocytes; in vitro study; enzyme linked immunosorbent assay; monoclonal antibody; thymus; infant; azathioprine; acquired immune deficiency syndrome; acquired immunodeficiency syndrome; drug therapy; thymosin; therapy; intravenous drug administration; human immunodeficiency virus 1; thymosin alpha1; phytohemagglutinin; concanavalin a; humans; human; priority journal; lymphokine; thymulin; thymic factor, circulating; thymus hormones; deltaretrovirus; pokeweed mitogen; blood and hemopoietic system |
| Journal Title: | Journal of Pediatrics |
| Volume: | 109 |
| Issue: | 3 |
| ISSN: | 0022-3476 |
| Publisher: | Elsevier Inc. |
| Date Published: | 1986-09-01 |
| Start Page: | 422 |
| End Page: | 427 |
| Language: | English |
| DOI: | 10.1016/s0022-3476(86)80111-1 |
| PUBMED: | 3018210 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Article -- Export Date: 18 August 2021 -- Source: Scopus |
