Analysis of T cell subsets in different clinical subgroups of patients with the acquired immune deficiency syndrome. Comparison with the "classic" form of Kaposi's sarcoma Journal Article

  

Authors:	Mittelman, A.; Wong, G.; Safai, B.; Myskowski, P.; Gold, J.; Koziner, B.
Article Title:	Analysis of T cell subsets in different clinical subgroups of patients with the acquired immune deficiency syndrome. Comparison with the "classic" form of Kaposi's sarcoma
Abstract:	Ninety patients were grouped according to three different forms of acquired immune deficiency syndrome (AIDS): Kaposl's sarcoma "recent outbreak" type (38), reactive lymphadenopathy (27), and opportunistic infections (17), and a fourth group of patients with "classic" Kaposl's sarcoma (8). All patients with "classic" Kaposi's sarcoma were previously treated with electron-beam irradiation. These four groups were compared with 40 normal control subjects. Peripheral blood mononuclear cells isolated by density separation were reacted with a panel of mouse monoclonal antibodies that recognizes all peripheral blood T cells (OKT3-positive), helper (OKT4-positive), and suppressor (OKT8-positive) T cell subsets. The OKT4/OKT8 ratio was used to define the balance between these two subsets. All three groups with AIDS with or without Kaposi's sarcoma showed a decrease in the OKT4/OKT8 ratio. The group with "classic" Kaposi's sarcoma showed individual T cell subset values that were also abnormal. These findings confirm the previously reported imbalance of T cell subsets in patients with AIDS and Kaposi's sarcoma, which is also evident in patients with treated "classic" Kaposl's sarcoma. © 1985.
Keywords:	adult; middle aged; major clinical study; lymph nodes; t lymphocyte; t-lymphocytes; biopsy; monoclonal antibody; lymphatic system; antibodies, monoclonal; diagnosis; hyperplasia; acquired immune deficiency syndrome; acquired immunodeficiency syndrome; kaposi sarcoma; sarcoma, kaposi; lymphadenopathy; opportunistic infection; lymphocyte subpopulation; reticuloendothelial system; humans; human; male; priority journal; deltaretrovirus
Journal Title:	The American Journal of Medicine
Volume:	78
Issue:	6 Part 1
ISSN:	0002-9343
Publisher:	Elsevier Inc.
Date Published:	1985-06-01
Start Page:	951
End Page:	956
Language:	English
DOI:	10.1016/0002-9343(85)90217-7
PROVIDER:	scopus
PUBMED:	2990205
DOI/URL:	https://www.scopus.com/inward/record.uri?eid=2-s2.0-0021889098&doi=10.1016%2f0002-9343%2885%2990217-7&partnerID=40&md5=06e951a4a3eab7a0de26105316506c99
Notes:	Article -- Export Date: 26 October 2021 -- Source: Scopus

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