Differential expression of lymphokine-activated killer cells and natural killer cells in adoptive transfer experiments utilizing fractionated bone marrow Journal Article
| Authors: | Merluzzi, V. J.; Trail, P. A.; Last-Barney, K. |
| Article Title: | Differential expression of lymphokine-activated killer cells and natural killer cells in adoptive transfer experiments utilizing fractionated bone marrow |
| Abstract: | Precursors of murine natural killer (NK) cells and lymphokine-activated killer (LAK) cells can be distinguished by utilizing an adoptive transfer system in which donor bone marrow is fractionated on Percoll discontinous gradients. Although precursors of LAK cells are present in all fractions, one fraction (> 65% Percoll) contains LAK precursors and is depleted of NK precursors. Both in vitro NK activity and in vivo hybrid resistance is abrogated in recipients of bone marrow from the > 65% Percoll fraction, whereas LAK activity can be readily demonstrated. |
| Keywords: | nonhuman; t-lymphocytes; mouse; animal; mice; bone marrow cells; bone marrow; in vitro study; mice, inbred strains; species specificity; recombinant proteins; natural killer cell; adoptive transfer; killer cells, natural; bone marrow transplantation; cell separation; interleukin-2; immunization, passive; lymphokine activated killer cell; human; male; priority journal; precursor cell; support, u.s. gov't, p.h.s.; blood and hemopoietic system |
| Journal Title: | Journal of Immunology |
| Volume: | 137 |
| Issue: | 8 |
| ISSN: | 0022-1767 |
| Publisher: | The American Association of Immunologists, Inc |
| Date Published: | 1986-10-15 |
| Start Page: | 2425 |
| End Page: | 2427 |
| Language: | English |
| PUBMED: | 3531332 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Article -- Export Date: 18 August 2021 -- Source: Scopus |