Prognostic significance of terminal deoxynucleotidyl transferase activity in acute nonlymphoblastic leukemia Journal Article

  


Authors: Benedetto, P.; Mertelsmann, R.; Szatrowski, T. H.; Andreeff, M.; Gee, T.; Arlin, Z.; Kempin, S.; Clarkson, B.
Article Title: Prognostic significance of terminal deoxynucleotidyl transferase activity in acute nonlymphoblastic leukemia
Abstract: Bone marrow and/or peripheral blood samples from 133 (75%) of a total of 177 consecutive previously untreated protocol patients with acute nonlymphoblastic leukemia (ANLL) were analyzed for terminal deoxynucleotidyl transferase (TdT) activity at the time of presentation. Twenty-nine (22%) were found to exhibit TdT activity (≥ 0.10 U/108 cells, TdT+) as measured in a biochemical microassay. There were no differences between TdT+ as compared with TdT-negative (TdT-) patients with respect to age, sex, French-American-British (FAB) classification, or the presence of Auer's rods. Remission induction rates were higher for the TdT- patients, with 68% v 48% for the TdT+ patients (P = .05). TdT- patients also experienced longer remissions (P = .003) than TdT+ patients, especially in the Auer's rod-positive subgroup (P = .002). None of five patients with TdT+ ANLL treated with vincristine and prednisone as initial therapy achieved complete remission; all required induction regimens containing daunorubicin or amsacrine in combination with cytosine arabinoside and 6-thioguanine. It is concluded that TdT activity in ANLL indicates biphenotypia or lineage infidelity and is associated with a poor prognosis on chemotherapy protocols currently used for the treatment of ANLL.
Keywords: human cell; major clinical study; prednisone; cytarabine; bone marrow; vincristine; cancer regression; diagnosis; daunorubicin; dna nucleotidylexotransferase; therapy; tioguanine; acute nonlymphocytic leukemia; prognosis; human; priority journal; blood and hemopoietic system
Journal Title: Journal of Clinical Oncology
Volume: 4
Issue: 4
ISSN: 0732-183X
Publisher: American Society of Clinical Oncology  
Date Published: 1986-04-01
Start Page: 489
End Page: 495
Language: English
DOI: 10.1200/jco.1986.4.4.489
PROVIDER: scopus
PUBMED: 3958762
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-0022644622&doi=10.1200%2fJCO.1986.4.4.489&partnerID=40&md5=0c0e6e4aa96e4e8bfe37e132e3ebdea7
Notes: Article -- Export Date: 18 August 2021 -- Source: Scopus
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MSK Authors
  1. Bayard Clarkson
    220 Clarkson
  2. Timothy Gee
    46 Gee
  3. Michael Andreeff
    70 Andreeff
  4. Sanford Kempin
    35 Kempin
  5. Roland Mertelsmann
    32 Mertelsmann
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