Human pluripotent hemopoietic colony stimulating factor: Activities on human and murine cells Journal Article

  


Authors: Platzer, E.; Oez, S.; Welte, K.; Sendler, A.; Gabrilove, J. L.; Mertelsmann, R.; Moore, M. A. S.; Kalden, J. R.
Article Title: Human pluripotent hemopoietic colony stimulating factor: Activities on human and murine cells
Abstract: Human pluripotent colony stimulating factor (Pluripoietin) was shown to act synergistically with human pluripotent alpha-like colony-stimulating activity (Pluripoietin-alpha) supporting the proliferation and differentiation of human CFU-GM progenitor cells in vitro, increasing colony size and numbers. In addition, Pluripoietin enhanced cytotoxic activity of mature human neutrophil granulocytes in an antibody-dependent cellular cytotoxicity assay. Biological activities of Pluripoietin known so far suggest great potentials for clinical use. Preclinical in vivo studies of Pluripoietin in different disease situations may be feasible in mice, because Pluripoietin is active on granulocyte precursors and on a variety of other murine cells. © 1986, Gustav Fischer Verlag · Stuttgart · New York. All rights reserved.
Keywords: human cell; drug efficacy; mouse; animals; mice; bone marrow cells; cell survival; cell cycle; interleukin 2; in vitro study; drug synergism; mice, inbred strains; hematopoiesis; neutrophils; colony-forming units assay; colony-stimulating factors; granulocyte; colony forming unit gm; antibody dependent cellular cytotoxicity; growth substances; colony formation; colony stimulating factor; antibody-dependent cell cytotoxicity; humans; human; priority journal; blood and hemopoietic system
Journal Title: Immunobiology
Volume: 172
Issue: 3-5
ISSN: 0171-2985
Publisher: Elsevier Inc.  
Date Published: 1986-09-01
Start Page: 185
End Page: 193
Language: English
DOI: 10.1016/s0171-2985(86)80098-5
PUBMED: 3492429
PROVIDER: scopus
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-0022526508&doi=10.1016%2fS0171-2985%2886%2980098-5&partnerID=40&md5=8fa86cbe88dc5c94e6679f8cb655ae32
Notes: Article -- Export Date: 18 August 2021 -- Source: Scopus
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MSK Authors
  1. Malcolm A S Moore
    549 Moore
  2. Janice Gabrilove
    122 Gabrilove
  3. Karl Welte
    77 Welte
  4. Roland Mertelsmann
    32 Mertelsmann
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