The influence of genetic background and the homologous chromosome 17 on t-haplotype transmission ratio distortion in mice Journal Article
| Authors: | Gummere, G. R.; McCormick, P. J.; Bennett, D. |
| Article Title: | The influence of genetic background and the homologous chromosome 17 on t-haplotype transmission ratio distortion in mice |
| Abstract: | Transmission ratio distortion is a characteristic of complete t-haplotypes, such that heterozygous males preferentially transmit the t-haplotype bearing chromosome 17 to the majority of their progeny. At least two genes contained within the t-haplotype have been identified as being required for such high transmission ratios. In this study we examine the effects of the gentic background and the chromosome homologous to the t-haplotype on transmission ratio distortion. We use two different congenic lines: (1) BTBRTF/Nev.Ttf/t12, in which the t12 haplotype has a transmission ratio of 52%, and (2) C3H/DiSn.Ttf/t12, in which the t12 haplotype has a transmission ratio of 99%. By intercrossing these two strains to produce reciprocal F1 and F2 generations, we have isolated the effects of the homologous chromosome 17 from the effects of the genetic background. We demonstrate that both the homologous chromosome and the genetic background have profound effects on t-haplotype transmission ratio distortion. Furthermore, it is evident that the t-haplotype transmission ratio behaves as a quantitative character rather than an intrinsic property of t-haplotypes. |
| Keywords: | nonhuman; comparative study; animal cell; mouse; animal; cytology; mice; heredity; mice, mutant strains; haplotypes; heterozygote; sex ratio; haplotype; analysis of variance; genetic marker; chromosome 17; chromosome mapping; etiology; crosses, genetic; population genetics; male; female; support, u.s. gov't, p.h.s.; ethnic or racial aspects |
| Journal Title: | Genetics |
| Volume: | 114 |
| Issue: | 1 |
| ISSN: | 0016-6731 |
| Publisher: | Genetics Society of America |
| Date Published: | 1986-09-01 |
| Start Page: | 235 |
| End Page: | 245 |
| Language: | English |
| PUBMED: | 3770466 |
| PROVIDER: | scopus |
| PMCID: | PMC1202933 |
| DOI: | 10.1093/genetics/114.1.235 |
| DOI/URL: | |
| Notes: | Article -- Export Date: 18 August 2021 -- Source: Scopus |
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