Transmission distortion of t-haplotypes is due to interactions between meiotic partners Journal Article
| Authors: | Seitz, A. W.; Bennett, D. |
| Article Title: | Transmission distortion of t-haplotypes is due to interactions between meiotic partners |
| Abstract: | The T/t-complex of the mouse includes a series of recessive lethal and semi-lethal mutations but, despite such lethalities, mutant t-haplotypes are found in high frequency in wild mouse populations1. This polymorphism is apparently maintained because heterozygous males preferentially transmit the t-bearing chromosome to their offspring2. Despite many attempts to define the basis of the transmission ratio distortion3-10, it has been unclear whether this is because t-bearing sperm have better than average fertilizing ability or whether +-bearing sperm in heterozygous males are rendered defective. To examine this point, we constructed male (XY ↔ XY) chimaeras containing +/+ and +/tw73 genotypes, marked respectively by albino and pigmented coat colours, and two isozyme variants. Such males produce a mixture of three different sperm types: +-bearing sperm from the +/+ genotype, +-bearing sperm from the +/t genotype, and t-bearing sperm from the +/t genotype. Appropriate matings can distinguish between these three types, and our data, reported here, show that t-bearing sperm in chimaeric mice maintain their advantage over their 'meiotic partners' but do not have any advantage over sperm from the +/+ genotype. © 1985 Nature Publishing Group. |
| Keywords: | nonhuman; mouse; animal; meiosis; mice; heredity; embryo; animal experiment; alleles; haplotype; chimera; genetic marker; genes, lethal; spermatogenesis; male; priority journal; polymorphism (genetics); support, u.s. gov't, p.h.s.; congenital disorder |
| Journal Title: | Nature |
| Volume: | 313 |
| Issue: | 5998 |
| ISSN: | 0028-0836 |
| Publisher: | Nature Publishing Group |
| Date Published: | 1985-01-10 |
| Start Page: | 143 |
| End Page: | 144 |
| Language: | English |
| DOI: | 10.1038/313143a0 |
| PROVIDER: | scopus |
| PUBMED: | 3965975 |
| DOI/URL: | |
| Notes: | Article -- Export Date: 26 October 2021 -- Source: Scopus |
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