Preaching about the converted: How meiotic gene conversion influences genomic diversity Conference Paper
| Authors: | Cole, F.; Keeney, S.; Jasin, M. |
| Title: | Preaching about the converted: How meiotic gene conversion influences genomic diversity |
| Conference Title: | DIMACS Conference on Effects of Genome Structure and Sequence on the Generation of Variation and Evolution |
| Abstract: | Meiotic crossover (CO) recombination involves a reciprocal exchange between homologous chromosomes. COs are often associated with gene conversion at the exchange site where genetic information is unidirectionally transferred from one chromosome to the other. COs and independent assortment of homologous chromosomes contribute significantly to the promotion of genomic diversity. What has not been appreciated is the contribution of another product of meiotic recombination, noncrossovers (NCOs), which result in gene conversion without exchange of flanking markers. Here, we review our comprehensive analysis of recombination at a highly polymorphic mouse hotspot. We found that NCOs make up ~90% of recombination events. Preferential recombination initiation on one chromosome allowed us to estimate the contribution of CO and NCO gene conversion to transmission distortion, a deviation from Mendelian inheritance in the population. While NCO gene conversion tracts are shorter, and thus have a more punctate effect, their higher frequency translates into an approximately two-fold greater contribution than COs to gene conversion-based allelic shuffling and transmission distortion. We discuss the potential impact of mammalian NCO characteristics on evolution and genomic diversity. © 2012 New York Academy of Sciences.. |
| Keywords: | meiosis; gene conversion; recombination; hotspot; noncrossover |
| Journal Title | Annals of the New York Academy of Sciences |
| Volume: | 1267 |
| Issue: | 1 |
| Conference Dates: | 2011 Aug 9-11 |
| Conference Location: | New Brunswick, NJ |
| ISBN: | 0077-8923 |
| Publisher: | John Wiley & Sons |
| Date Published: | 2012-09-01 |
| Start Page: | 95 |
| End Page: | 102 |
| Language: | English |
| DOI: | 10.1111/j.1749-6632.2012.06595.x |
| PROVIDER: | scopus |
| PUBMED: | 22954222 |
| PMCID: | PMC3625938 |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 4" - "Export Date: 1 October 2012" - "CODEN: ANYAA" - "Source: Scopus" |
Altmetric
Citation Impact
BMJ Impact Analytics
Related MSK Work