Potentiation of radiation effects on two murine tumors by lonidamine Journal Article
| Authors: | Kim, J. H.; Alfieri, A. A.; Kim, S. H.; Young, C. W. |
| Article Title: | Potentiation of radiation effects on two murine tumors by lonidamine |
| Abstract: | Lonidamine is a potent inhibitor of spermatogenesis and a hyperthermic sensitizer. The principal established locus of biochemical action of lonidamine is a selective inhibitory effect of the energy metabolism either in NAD-linked reactions in germ cell mitochondria, as well as the glycolytic metabolism of a variety of tumor cell lines by means of inhibition of mitochondrially bound hexokinase. We carried out in vivo tumor experiments to determine whether lonidamine when combined with radiation could potentiate the cytotoxic effects of radiation on two murine tumors. The combined effects of single acute lonidamine (100 mg/ kg) and single dose X-irradiation were evaluated on the transplanted methylcholanthrene–induced fibrosarcoma in BALB/c mice and on the radiation–induced fibrosarcoma in C3H/He mice. The radiosensitizing effect by lonidamine was maximal when lonidamine was administered immediately prior to or after X-irradiation. The dose modifying factor of lonidamine is estimated to be 1.36 for methylcholanthrene–induced fibrosarcoma tumors and 1.25 for radiation–induced fibrosarcorna tumors. There was no disproportionately enhanced skin reaction following the combined treatments. The present results of the potentiating effects of radiation may be attributed, in part, to the findings of cell culture studies that lonidamine is a potent inhibitor of repair of potentially lethal damage. © 1986, American Association for Cancer Research. All rights reserved. |
| Keywords: | cisplatin; doxorubicin; drug efficacy; nonhuman; cancer radiotherapy; methotrexate; mouse; animal; mice; drug administration schedule; animal model; dose-response relationship, drug; radiation response; time factors; dose-response relationship, radiation; skin; lung metastasis; fibrosarcoma; pyrazoles; neoplasms, experimental; metabolic clearance rate; radiosensitizing agent; radiation-sensitizing agents; energy metabolism; lonidamine; indazoles; respiratory system; potentiation; intraperitoneal drug administration; priority journal; support, u.s. gov't, p.h.s. |
| Journal Title: | Cancer Research |
| Volume: | 46 |
| Issue: | 3 |
| ISSN: | 0008-5472 |
| Publisher: | American Association for Cancer Research |
| Date Published: | 1986-03-01 |
| Start Page: | 1120 |
| End Page: | 1123 |
| Language: | English |
| PUBMED: | 3943089 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Article -- Export Date: 18 August 2021 -- Source: Scopus |
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