Radiosensitization of two murine fibrosarcomas with 6-thioguanine Journal Article
| Authors: | Kim, J. H.; Alfieri, A. A.; Kim, S. H.; Hong, S. S. |
| Article Title: | Radiosensitization of two murine fibrosarcomas with 6-thioguanine |
| Abstract: | in vivo murine tumor experiments were carried out to determine whether 6-thioguanine (6-TG) could enhance the cytotoxic effects of radiation on tumors. The combined effects of single and fractionated x-irradiation were evaluated on the transplanted methylcholanthrene induced fibrosarcoma (Meth-A) in BALB/c mice, a moderately radio-responsive tumor and on the radiation induced fibrosarcoma (RIF) in C3H/He mice, a highly radioresistant tumor. The combined treatment of single administration of 6-TG (25 mg/kg) and of x-irradiation (20 Gy) on Meth-A tummor produced more than 90% tumor control, whereas the radiation alone resulted in less than 5% tumor control. The radiosensitizing effect by 6-TG was higher when the drug was administered either I to 8 hr prior to or 24 hr after x-irradiation. The dose modification factor of single dose 6-TG (10 mg/kg) is estimated to be 1.47 for Meth-A tumor and 1.25 for RIF tumor. The tumor control rates of fractionated irradiation alone and with concomitant 6-TG in Meth-A tumors were 14% and 59%, respectively. Based on the studies reported here and well documented pharmacokinetics in humans, it is suggested that combined radiation therapy and 6-TG may provide an enhanced therapeutic effect even in tumor varieties where the drug has no apparent anti-tumor activity on non-irradiated cells. © 1990. |
| Keywords: | combined modality therapy; methodology; mouse; animal; mice; radiotherapy; animal experiment; mice, inbred balb c; dose-response relationship, radiation; fibrosarcoma; neoplasms, radiation-induced; radiation therapy; neoplasm transplantation; drug therapy; radiation-sensitizing agents; tioguanine; x irradiation; radiosensitization; mice, inbred c3h; murine tumors; cancer graft; methylcholanthrene; male; priority journal; article; support, u.s. gov't, p.h.s.; 6-thioguanine; thioguanine |
| Journal Title: | International Journal of Radiation Oncology, Biology, Physics |
| Volume: | 18 |
| Issue: | 3 |
| ISSN: | 0360-3016 |
| Publisher: | Elsevier Inc. |
| Date Published: | 1990-03-01 |
| Start Page: | 583 |
| End Page: | 586 |
| Language: | English |
| DOI: | 10.1016/0360-3016(90)90064-q |
| PUBMED: | 2318691 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Source: Scopus |
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