Radiosensitization of two murine fibrosarcomas with 6-thioguanine Journal Article


Authors: Kim, J. H.; Alfieri, A. A.; Kim, S. H.; Hong, S. S.
Article Title: Radiosensitization of two murine fibrosarcomas with 6-thioguanine
Abstract: in vivo murine tumor experiments were carried out to determine whether 6-thioguanine (6-TG) could enhance the cytotoxic effects of radiation on tumors. The combined effects of single and fractionated x-irradiation were evaluated on the transplanted methylcholanthrene induced fibrosarcoma (Meth-A) in BALB/c mice, a moderately radio-responsive tumor and on the radiation induced fibrosarcoma (RIF) in C3H/He mice, a highly radioresistant tumor. The combined treatment of single administration of 6-TG (25 mg/kg) and of x-irradiation (20 Gy) on Meth-A tummor produced more than 90% tumor control, whereas the radiation alone resulted in less than 5% tumor control. The radiosensitizing effect by 6-TG was higher when the drug was administered either I to 8 hr prior to or 24 hr after x-irradiation. The dose modification factor of single dose 6-TG (10 mg/kg) is estimated to be 1.47 for Meth-A tumor and 1.25 for RIF tumor. The tumor control rates of fractionated irradiation alone and with concomitant 6-TG in Meth-A tumors were 14% and 59%, respectively. Based on the studies reported here and well documented pharmacokinetics in humans, it is suggested that combined radiation therapy and 6-TG may provide an enhanced therapeutic effect even in tumor varieties where the drug has no apparent anti-tumor activity on non-irradiated cells. © 1990.
Keywords: combined modality therapy; methodology; mouse; animal; mice; radiotherapy; animal experiment; mice, inbred balb c; dose-response relationship, radiation; fibrosarcoma; neoplasms, radiation-induced; radiation therapy; neoplasm transplantation; drug therapy; radiation-sensitizing agents; tioguanine; x irradiation; radiosensitization; mice, inbred c3h; murine tumors; cancer graft; methylcholanthrene; male; priority journal; article; support, u.s. gov't, p.h.s.; 6-thioguanine; thioguanine
Journal Title: International Journal of Radiation Oncology, Biology, Physics
Volume: 18
Issue: 3
ISSN: 0360-3016
Publisher: Elsevier Inc.  
Date Published: 1990-03-01
Start Page: 583
End Page: 586
Language: English
DOI: 10.1016/0360-3016(90)90064-q
PUBMED: 2318691
PROVIDER: scopus
DOI/URL:
Notes: Source: Scopus
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  1. Alan A. Alfieri
    35 Alfieri
  2. Jae Ho Kim
    25 Kim