Time dependence of the radiation-modifying effect of cis-diamminedichloroplatinum II (cisplatin, DDP) on human urothelial cancer grown in nude mice Journal Article
| Authors: | Kyriazis, A. P.; Kyriazis, A. A.; Yagoda, A. |
| Article Title: | Time dependence of the radiation-modifying effect of cis-diamminedichloroplatinum II (cisplatin, DDP) on human urothelial cancer grown in nude mice |
| Abstract: | Previous reports have indicated that human urothelial cancer is more sensitive to combination radiation-cisplatin than to either treatment given alone and that the treatment schedule may be an important factor in determining the magnitude of tumor response. In the present study we have investigated the effect of timing and the sequence of combination (radiation-cisplatin) on human urothelial cancer grown in nude mice. Tumors were exposed to 1000 rod x-irradiation and received cisplatin treatment in the amount of 5 mg/kg once on each specified day before or after radiation. Best tumor responses, characterized by significant tumor growth delay and tumor regression, were observed when cisplatin was given on Day 3 and 6 postradiation. The present work has indicated that timing and sequence of treatments in the combination (radiation-cisplatin) are important factors in determining tumor response and may be of assistance in formulating the most effective clinical trials of urothelial cancer patients. © 1986 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted. |
| Keywords: | human cell; cisplatin; combined modality therapy; mouse; animal; mice; drug administration schedule; cell line; animal model; mice, inbred balb c; urologic neoplasms; nude mouse; mice, nude; urinary tract cancer; carcinoma, transitional cell; urinary tract; radiosensitization; random allocation; intraperitoneal drug administration; cancer graft; human; female; support, u.s. gov't, p.h.s. |
| Journal Title: | Cancer Investigation |
| Volume: | 4 |
| Issue: | 3 |
| ISSN: | 0735-7907 |
| Publisher: | Informa Healthcare |
| Date Published: | 1986-01-01 |
| Start Page: | 217 |
| End Page: | 222 |
| Language: | English |
| DOI: | 10.3109/07357908609018451 |
| PUBMED: | 3719411 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Article -- Export Date: 18 August 2021 -- Source: Scopus |
