Further characterization of a transplantable murine osteogenic sarcoma Journal Article
| Authors: | Russ, G. A.; Sordillo, P. P.; Baronofsky, D. R.; Huvos, A. G. |
| Article Title: | Further characterization of a transplantable murine osteogenic sarcoma |
| Abstract: | A transplantable murine osteogenic sarcoma was characterized to determine its suitability as a model for human cancer and to evaluate specific end points to study therapeutic intervention. Palpable tumors developed at implantation sites following latent periods of 8 to 21 days and grew to 3 g masses within 60 days. The tumor model was predictable in its manner of tumor growth, tumor production of alkaline phosphatase, formation of pulmonary metastases, and the survival of the host. It was found to be sensitive to treatment with cyclophosphamide and vincristine and to a lesser extent to adriamycin and 41-epi-adriamycin. It did not show a response to treatment with cis-platinum, actinomycin D, or m-AMSA. Survival of the host is limited by the progression of metastatic disease and local control does not appreciably extend the median survival time. Thus, population survival should be used as a measure of the effectiveness of treatment of pulmonary metastases. Circulating alkaline phosphatase levels may best be used in assessing the response to treatment of the primary osteogenic sarcoma. © 1986 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted. |
| Keywords: | osteosarcoma; survival; human cell; cisplatin; doxorubicin; cancer combination chemotherapy; antineoplastic agents; mouse; animal; mice; lung neoplasms; animal model; cyclophosphamide; vincristine; dose-response relationship, drug; transplantation; cancer model; alkaline phosphatase; bone; neoplasm metastasis; dactinomycin; epirubicin; amsacrine; neoplasm transplantation; therapy; mice, inbred c3h; characterization; intraperitoneal drug administration; human; support, non-u.s. gov't; support, u.s. gov't, p.h.s. |
| Journal Title: | Cancer Investigation |
| Volume: | 4 |
| Issue: | 6 |
| ISSN: | 0735-7907 |
| Publisher: | Informa Healthcare |
| Date Published: | 1986-01-01 |
| Start Page: | 535 |
| End Page: | 541 |
| Language: | English |
| DOI: | 10.3109/07357908609039833 |
| PUBMED: | 3470107 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Article -- Export Date: 18 August 2021 -- Source: Scopus; Acknowledgments: The authors express their gratitude to Drs. Raymond N. Hiromoto and V. K. Ghanta, Dept of Microbiology, University of Alabama Medical Center, for their kind gift of the murine osteogenic sarcoma and for their assistance and advice in the development of the methodology described, to Dr. Helen Q. Woodard, Biophysics Laboratory, MSKCC, for her counsel and guidance during the period of this study and to Dr. John S. Laughlin, Head, Biophysics Laboratory, MSKCC, for his encouragement and support. |
Altmetric
Citation Impact
BMJ Impact Analytics
Related MSK Work