De novo osteogenic sarcoma in patients older than forty: Benefit of multimodality therapy Journal Article
| Authors: | Manoso, M. W.; Healey, J. H.; Boland, P. J.; Athanasian, E. A.; Maki, R. G.; Huvos, A. G.; Morris, C. D. |
| Article Title: | De novo osteogenic sarcoma in patients older than forty: Benefit of multimodality therapy |
| Abstract: | The treatment of primary osteogenic sarcoma is well established in younger patients; however, controversy surrounds the treatment of this disease in the older population. To confirm multimodality therapy results in longer survival than surgery alone, 58 patients older than 40 years with primary osteogenic sarcoma were assessed retrospectively for the benefits of multimodality treatment versus surgery alone. We then asked whether specific patient and tumor characteristics and treatment modalities affected the rates of survival. Finally, we questioned whether pulmonary metastatectomy increased survival. The 5-year and 10-year overall survival for the group was 58% and 44%, respectively. Multimodality therapy increased survival compared with surgery alone in patients with high-grade disease. On multivariate analysis, considerable prognostic factors for improved overall survival for the entire group were age younger than 60 years, volume less than 100 cm3, normal alkaline phosphatase, localized disease, negative surgical margins, and absence of recurrence. Pulmonary metastatectomy improved survival in selected patients. Level of Evidence: Therapeutic study, Level III-1 (retrospective cohort study). © 2005 Lippincott Williams & Wilkins. |
| Keywords: | osteosarcoma; adult; cancer survival; controlled study; aged; aged, 80 and over; bone neoplasms; middle aged; bone tumor; cancer surgery; survival rate; retrospective studies; major clinical study; mortality; cisplatin; doxorubicin; cancer combination chemotherapy; multimodality cancer therapy; side effect; conference paper; combined modality therapy; methotrexate; evidence based medicine; evidence-based medicine; metastasis; neoplasm recurrence, local; tumor volume; etoposide; blood toxicity; lung neoplasms; cyclophosphamide; vincristine; kidney failure; age factors; pathology; retrospective study; ifosfamide; age; lung tumor; survival time; lung metastasis; tumor recurrence; neoplasm metastasis; dactinomycin; bleomycin; alkaline phosphatase blood level; age distribution |
| Journal Title: | Clinical Orthopaedics and Related Research |
| Volume: | 438 |
| ISSN: | 0009-921X |
| Publisher: | Springer |
| Date Published: | 2005-09-01 |
| Start Page: | 110 |
| End Page: | 115 |
| Language: | English |
| DOI: | 10.1097/01.blo.0000179587.42350.4d |
| PUBMED: | 16131878 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - Article; Proceedings Paper - Annual Meeting of the Musculoskeletal-Tumor-Society - JUL, 2004 - Long Beach, CA - "Cited By (since 1996): 8" - "Export Date: 24 October 2012" - "CODEN: CORTB" - "Source: Scopus" |
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