Mycobacterium avium complex infections in patients with the acquired immunodeficiency syndrome Journal Article

  


Authors: Hawkins, C. C.; Gold, J. W. M.; Whimbey, E.; Kiehn, T. E.; Brannon, P.; Cammarata, R.; Brown, A. E.; Armstrong, D.
Article Title: Mycobacterium avium complex infections in patients with the acquired immunodeficiency syndrome
Abstract: Disseminated infection with Mycobacterium avium complex developed in 67 patients with the acquired immunodeficiency syndrome (AIDS) who were followed at Memorial Sloan-Kettering Cancer Center. Twenty-nine patients were treated with two or more antimycobacterial drugs for a mean of 6 weeks, and 7 patients received therapy for less than 1 month. Most patients received ansamycin, clofazimine, and ethionamide or ethambutol. Clinical improvement did not occur in treated patients, and microbiologic cure was never obtained. Mycobacterial bacteremia persisted in 24 of 26 treated patients. Colony counts of M. avium complex in sequential blood cultures decreased in 3 patients. Every autopsied patient with M. avium complex infection diagnosed before death, whether treated or not, had disseminated M. avium complex infection at autopsy.
Keywords: clinical article; chemotherapy; lymphatic system; diagnosis; acquired immune deficiency syndrome; drug therapy; rifampicin; therapy; intravenous drug administration; oral drug administration; drug indication; streptomycin; ansamycin derivative; clofazimine; ethambutol; isoniazid; cycloserine; mycobacterium avium; human; priority journal; ethionamide
Journal Title: Annals of Internal Medicine
Volume: 105
Issue: 2
ISSN: 0003-4819
Publisher: American College of Physicians  
Date Published: 1986-08-01
Start Page: 184
End Page: 188
Language: English
DOI: 10.7326/0003-4819-105-2-184
PROVIDER: scopus
PUBMED: 3729201
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-0022467937&doi=10.7326%2f0003-4819-105-2-184&partnerID=40&md5=a40f09bbfee83cf2013301ff96252414
Notes: Article -- Export Date: 18 August 2021 -- Source: Scopus; Acknowledgments: The authors thank the residents and attending physicians of the Department of Pathology of MSK for their assistance; and Maria C. Rodriguez for help in preparing this manuscript.
Altmetric
What is Altmetric?
Citation Impact
What is Dimensions Citation Badge?
BMJ Impact Analytics
MSK Authors
  1. Timothy E Kiehn
    100 Kiehn
  2. Arthur E Brown
    76 Brown
  3. Donald Armstrong
    240 Armstrong
  4. Jonathan W. M. Gold
    73 Gold
Related MSK Work