Progressive disseminated infection with Mycobacterium avium complex after intravenous and oral challenge in cyclosporine-treated rats Journal Article

  

Authors:	Brown, S. T.; Edwards, F. F.; Bernard, E. M.; Niki, Y.; Armstrong, D.
Article Title:	Progressive disseminated infection with Mycobacterium avium complex after intravenous and oral challenge in cyclosporine-treated rats
Abstract:	Male Sprague-Dawley rats, immunosuppressed with cyclosporine (CsA), developed disseminated infection after intravenous or oral challenge with Mycobacterium avium complex (MAC). Disseminated infection leading to bacillemia could be established after intravenous inoculation with as few as 5 × 103 organisms. When CsA was not given or when CsA was stopped 1 month after infection, animals cleared the bacilli from blood and tissue. Animals developed disseminated infection after oral challenge with as few as 106 organisms. Persistent bacillemia occurred when organisms in the spleen exceeded 107. Differences in virulence among strains were observed. Infected tissues showed histopathologic changes similar to those seen in patients with AIDS. The CsA-treated rat is a new model that appears useful for studies of the virulence, of MAC strains and the pathogenesis of disseminated MAC infection.
Keywords:	pathogenesis; nonhuman; animal; animal experiment; animal model; bacterial virulence; rat; rats; bacteremia; acquired immunodeficiency syndrome; disease models, animal; administration, oral; feces; cyclosporin; cyclosporine; mycobacteriosis; oral drug administration; immunosuppression; provocation test; rats, inbred strains; mycobacterium avium; human; male; priority journal; article; mycobacterium avium-intracellulare infection; support, u.s. gov't, p.h.s.; mycobacterium avium complex
Journal Title:	Journal of Infectious Diseases
Volume:	164
Issue:	5
ISSN:	0022-1899
Publisher:	Oxford University Press
Date Published:	1991-11-01
Start Page:	922
End Page:	927
Language:	English
DOI:	10.1093/infdis/164.5.922
PUBMED:	1940470
PROVIDER:	scopus
DOI/URL:	https://www.scopus.com/inward/record.uri?eid=2-s2.0-0026064616&doi=10.1093%2finfdis%2f164.5.922&partnerID=40&md5=5542eeb33946967cddc2a800fcebe70e
Notes:	Article -- Export Date: 27 September 2019 -- Source: Scopus

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