Pulmonary Kaposi's sarcoma in the acquired immune deficiency syndrome: Clinical, radiographic, and pathologic manifestations Journal Article

  


Authors: Meduri, G. U.; Stover, D. E.; Lee, M.; Myskowski, P. L.; Caravelli, J. F.; Zaman, M. B.
Article Title: Pulmonary Kaposi's sarcoma in the acquired immune deficiency syndrome: Clinical, radiographic, and pathologic manifestations
Abstract: Pulmonary Kaposl's sarcoma related to the acquired Immune deficiency syndrome (AIDS) has not been well characterized. To define the clinical, radiographic, and pathologic features of this entity, 11 autopsy-proved cases of pulmonary Kaposi's sarcoma were reviewed. The most common clinical symptoms were dyspnea and cough, but hemoptysis and stridor were also found. Nodular Infiltrates and pleural effusions were the most commonly found radiographic abnormalities. Pulmonary function tests were sensitive in detecting the pulmonary abnormalities due to Kaposl's sarcoma. A low diffusion capacity, lack of arterial desaturation with exercise, and obstruction to airflow were suggestive of pulmonary involvement with this malignancy. Although endobronchial Kaposi's sarcoma was visualized at bronchoscopy as cherry-red, slightly raised lesions, bronchial biopsy specimens always showed no abnormalities. Transbronchial brushings and biopsy specimens and analysis of pleural fluid were also not helpful in establishing a diagnosis. In the seven subjects with extensive parenchymal Kaposl's sarcoma at autopsy, the pleura was always involved. Eight subjects had involvement of the tracheobronchial tree. In all of the subjects, pulmonary Kaposl's sarcoma was a significant cause of morbidity, and in three of 11 subjects (27 percent) it was the direct cause of death. © 1986.
Keywords: adult; middle aged; histopathology; lung neoplasms; histology; lung; bronchoscopy; acquired immune deficiency syndrome; acquired immunodeficiency syndrome; kaposi sarcoma; sarcoma, kaposi; autopsy; human immunodeficiency virus 1; pulmonary diffusing capacity; respiratory system; vital capacity; humans; human; male; priority journal; pulmonary ventilation; blood and hemopoietic system
Journal Title: The American Journal of Medicine
Volume: 81
Issue: 1
ISSN: 0002-9343
Publisher: Elsevier Inc.  
Date Published: 1986-07-01
Start Page: 11
End Page: 18
Language: English
DOI: 10.1016/0002-9343(86)90175-0
PUBMED: 3728535
PROVIDER: scopus
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-0022530891&doi=10.1016%2f0002-9343%2886%2990175-0&partnerID=40&md5=6ec39e595bf4ddf569b9a412810610f2
Notes: Article -- Export Date: 18 August 2021 -- Source: Scopus
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MSK Authors
  1. Diane E Stover-Pepe
    109 Stover-Pepe
  2. James F Caravelli
    39 Caravelli
  3. Patricia Myskowski
    216 Myskowski
  4. Muhammad B Zaman
    19 Zaman
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