Spectrum of pulmonary diseases associated with the acquired immune deficiency syndrome Journal Article


Authors: Stover, D. E.; White, D. A.; Romano, P. A.; Gellene, R. A.; Robeson, W. A.
Article Title: Spectrum of pulmonary diseases associated with the acquired immune deficiency syndrome
Abstract: Over a four-year period, 130 patients with the acquired immune deficiency syndrome were studied to assess the incidence and spectrum of pulmonary disease associated with this illness. In 61 patients (47 percent), respiratory abnormalities were either present on admission or later developed. Multiple pathologic processes were present simultaneously in 24 patients and serial pulmonary problems developed in seven patients. Infection was the most common cause of pulmonary parenchymal disease and was due to Pneumocystis carinil (35 patients), cytomegalovirus (21 patients), Mycobacterium avium-intracellulare (13 patients), and bacteria (four patients). Noninfectious causes of parenchymal lung diseases were also frequently seen and included Kaposi's sarcoma (eight patients), nonspecific pneumonitis (seven patients), and adult respiratory distress syndrome (four patients). Significant pleural disease was present In six cases and was usually related to Kaposi's sarcoma. A bronchospastic disorder developed in four patients. Pulmonary function tests, in particular the diffusing capacity and the difference between rest and exercise alveolar-arterial oxygen tension, were helpful in screening for pulmonary diseases. Patterns of clinical features and radiographic abnormalities were recognized and suggested specific diagnoses. Overall mortality from respiratory causes identified during the study was 41 percent, but varied markedly with the etiologic agent. Respiratory failure, however, carried a 100 percent mortality despite the underlying cause. © 1985.
Keywords: adult; aged; major clinical study; mortality; lung disease; pathology; biopsy; radiography; bronchoscopy; acquired immune deficiency syndrome; acquired immunodeficiency syndrome; kaposi sarcoma; epidemiology; bacterial infection; bacterial infections; lung function test; cytomegalovirus; lavage; respiratory insufficiency; respiratory failure; adult respiratory distress syndrome; airway obstruction; etiology; middle age; lung diseases; respiratory function tests; pleura disease; respiratory system; pneumocystis carinii; cytomegalovirus infections; pleural diseases; irrigation; pneumocystis carinii pneumonia; prognosis; human; male; female; priority journal; article; mycobacterium intracellulare avium; cytomegalic inclusion body disease; lung alveolus oxygen tension; pneumonia, pneumocystis carinii
Journal Title: The American Journal of Medicine
Volume: 78
Issue: 3
ISSN: 0002-9343
Publisher: Elsevier Inc.  
Date Published: 1985-03-01
Start Page: 429
End Page: 437
Language: English
DOI: 10.1016/0002-9343(85)90334-1
PUBMED: 2983548
PROVIDER: scopus
DOI/URL:
Notes: Article -- Export Date: 26 October 2021 -- Source: Scopus
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  1. Dorothy A White
    74 White