Addition of prostate volume and prostate-specific antigen density to Memorial Sloan Kettering Cancer Center prostate cancer nomograms Research Letter

   


Authors: Tzeng, M.; Vertosick, E.; Basourakos, S. P.; Eastham, J. A.; Ehdaie, B.; Scardino, P. T.; Vickers, A. J.; Hu, J. C.
Title: Addition of prostate volume and prostate-specific antigen density to Memorial Sloan Kettering Cancer Center prostate cancer nomograms
Abstract: Prostate-specific antigen (PSA) density is an established prognostic marker for prostate cancer. We investigated whether the inclusion of PSA density or prostate volume in the Memorial Sloan Kettering Cancer Center nomograms improves the prediction of biochemical recurrence (BCR) after radical prostatectomy (RP). Among the 11 725 men included, 2140 developed BCR. Neither PSA density nor prostate volume was associated with BCR when added to either the pre-RP or post-RP model (all p values ≥0.10) and changes in the C index were very small (largest change, 0.002). The results were robust to exclusion of outlying prostate volumes and restriction to patients treated after 2005. There is no justification for adding prostate volume or PSA density to BCR nomograms. Patient summary: Addition of prostate volume or prostate-specific antigen density to Memorial Sloan Kettering Cancer Center prediction schemes did not improve the prediction of recurrence of prostate cancer after removal of the prostate. © 2021 The Authors
Keywords: cancer survival; major clinical study; cancer recurrence; follow up; diagnostic accuracy; letter; sensitivity analysis; prostate specific antigen; disease association; cohort analysis; prostate cancer; prostate-specific antigen; cancer center; prostatectomy; radical prostatectomy; density; biochemical recurrence; nomogram; predictive value; prostate volume; cancer prognosis; human; male; prostate-specific antigen density
Journal Title: European Urology Open Science
Volume: 30
ISSN: 2666-1691
Publisher: Elsevier BV  
Date Published: 2021-08-01
Start Page: 13
End Page: 15
Language: English
DOI: 10.1016/j.euros.2021.06.002
PROVIDER: scopus
PMCID: PMC8317781
PUBMED: 34337542
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-85107919531&doi=10.1016%2fj.euros.2021.06.002&partnerID=40&md5=dd8e9196e6c82e5fb63b2db661c78124
Notes: Letter -- Export Date: 1 July 2021 -- Source: Scopus
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MSK Authors
  1. Peter T Scardino
    671 Scardino
  2. Andrew J Vickers
    880 Vickers
  3. Behfar Ehdaie
    173 Ehdaie
  4. James Eastham
    537 Eastham
  5. Emily Vertosick
    134 Vertosick
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