Assessment of the enhancement in predictive accuracy provided by systematic biopsy in predicting outcome for clinically localized prostate cancer Journal Article
| Authors: | Graefen, M.; Ohori, M.; Karakiewicz, P. I.; Cagiannos, I.; Hammerer, P. G.; Haese, A.; Erbersdobler, A.; Henke, R. P.; Huland, H.; Wheeler, T. M.; Slawin, K.; Scardino, P. T.; Kattan, M. W. |
| Article Title: | Assessment of the enhancement in predictive accuracy provided by systematic biopsy in predicting outcome for clinically localized prostate cancer |
| Abstract: | Purpose: Current localized prostate cancer treatment outcome nomograms rely on prostate specific antigen (PSA), tumor stage and grade. We investigated whether the addition of prostate biopsy features may enhance the accuracy of a nomogram predicting recurrence after radical prostatectomy (RP). Materials and Methods: Clinical data from 1,152 patients who underwent RP were used and included PSA, clinical stage, biopsy Gleason grade and systematic biopsy information that quantified the amount of cancer and high grade cancer. Predictive accuracy for freedom from recurrence after RP was assessed with and without tumor quantification in the biopsy by the area under the receiver operating characteristics curve (AUC). Results: Percentage and number of cores with cancer, and percentage and number of cores with high grade cancer were predictors of outcome when added to models that included PSA, Gleason grade and clinical stage (all p <0.0001). Nomogram accuracy with 3 traditional variables (AUC 0.790) was minimally enhanced with the addition of percentage or number of positive cores (AUC 0.804 and 0.800, respectively), or percentage or number of cores with high grade cancer (AUC 0.802 and 0.800, respectively), Maximum predictive accuracy of 0.811 was achieved after supplementing the traditional 3-variable nomogram with various combinations of additional pathological predictors. Conclusions: The information provided by systematic biopsies substantially improves the ability to predict outcome following RP, However, some incremental predictive accuracy was achieved by adding systematic biopsy features. |
| Keywords: | adult; human tissue; aged; middle aged; major clinical study; cancer recurrence; cancer staging; cancer grading; diagnostic accuracy; prostate specific antigen; reproducibility of results; neoplasm recurrence, local; biopsy; prostate cancer; prostatic neoplasms; prostate; prostatectomy; prostate biopsy; predictive value of tests; outcomes research; humans; prognosis; human; male; priority journal; article |
| Journal Title: | Journal of Urology |
| Volume: | 171 |
| Issue: | 1 |
| ISSN: | 0022-5347 |
| Publisher: | Elsevier Science, Inc. |
| Date Published: | 2004-01-01 |
| Start Page: | 200 |
| End Page: | 203 |
| Language: | English |
| DOI: | 10.1097/01.ju.0000099161.70713.c8 |
| PROVIDER: | scopus |
| PUBMED: | 14665876 |
| DOI/URL: | |
| Notes: | J. Urol. -- Cited By (since 1996):39 -- Export Date: 16 June 2014 -- CODEN: JOURA -- Source: Scopus |
Altmetric
Citation Impact
BMJ Impact Analytics
Related MSK Work