The chemotherapy-naive patient with metastatic colorectal cancer Journal Article

  


Author: Saltz, L.
Article Title: The chemotherapy-naive patient with metastatic colorectal cancer
Abstract: Colorectal cancer (CRC) tends to manifest with clinical symptoms usually only after the underlying disease process is well advanced. The task for managing chemotherapy-naive patients with metastatic CRC is to develop a treatment strategy that is appropriate for their overall level of function, preexisting comorbidities, and treatment preferences. FOLFIRI and FOLFOX have become the two most common cytotoxic regimens used in practice today, with data strongly suggesting their essentially equal effectiveness in the front line. Patients should be advised, however, that certain toxicities are more likely with one regimen in comparison with the other.
Keywords: cancer chemotherapy; cancer survival; treatment response; clinical trial; fatigue; neutropenia; bevacizumab; fluorouracil; cancer growth; diarrhea; drug efficacy; hypertension; unspecified side effect; capecitabine; neurotoxicity; laparoscopy; colorectal cancer; metastasis; liver toxicity; sensory neuropathy; mucosa inflammation; nausea; thrombocytopenia; vomiting; peripheral neuropathy; combination chemotherapy; irinotecan; febrile neutropenia; hospitalization; colonoscopy; folinic acid; medical practice; hyperbilirubinemia; symptomatology; liver function test; oxaliplatin; treatment contraindication; alopecia; beta adrenergic receptor blocking agent; non insulin dependent diabetes mellitus; fluoropyrimidine; colon adenocarcinoma; allergic reaction
Journal Title: Community Oncology
Volume: 4
Issue: 5 Suppl. 2
ISSN: 1548-5315
Publisher: Elsevier Inc.  
Date Published: 2007-05-01
Start Page: 5
End Page: 7
Language: English
PROVIDER: scopus
DOI/URL:

http://www.scopus.com/inward/record.url?eid=2-s2.0-34249776052&partnerID=40&md5=76f650af18039cb9ff0691bab83608f8
Notes: --- - "Cited By (since 1996): 1" - "Export Date: 17 November 2011" - "Source: Scopus"