The transcription factor Rreb1 regulates epithelial architecture, invasiveness and vasculogenesis in early mouse embryos Journal Article

   


Authors: Morgani, S. M.; Su, J.; Nichols, J.; Massagué, J.; Hadjantonakis, A. K.
Article Title: The transcription factor Rreb1 regulates epithelial architecture, invasiveness and vasculogenesis in early mouse embryos
Abstract: Ras-responsive element-binding protein 1 (Rreb1) is a zinc-finger transcription factor acting 38 downstream of RAS signaling. Rreb1 has been implicated in cancer and Noonan-like RASopathies. However, little is known about its role in mammalian non-disease states. Here, we show that Rreb1 is essential for mouse embryonic development. Loss of Rreb1 led to a reduction in the expression of vasculogenic factors, cardiovascular defects and embryonic lethality. During gastrulation, the absence of Rreb1 also resulted in the upregulation of cytoskeleton-associated genes, a change in the organization of F-ACTIN and adherens junctions within the pluripotent epiblast, and perturbed epithelial architecture. Moreover, Rreb1 mutant cells ectopically exited the epiblast epithelium through the underlying basement membrane, paralleling cell behaviors observed during metastasis. Thus, disentangling the function of Rreb1 in development should shed light on its role in cancer and other diseases involving loss of epithelial integrity. © 2021, eLife Sciences Publications Ltd. All rights reserved.
Journal Title: eLife
Volume: 10
ISSN: 2050-084X
Publisher: eLife Sciences Publications Ltd.  
Date Published: 2021-04-30
Start Page: e64811
Language: English
DOI: 10.7554/elife.64811
PUBMED: 33929320
PROVIDER: scopus
PMCID: PMC8131102
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-85106148917&doi=10.7554%2fELIFE.64811&partnerID=40&md5=cbb3666dd460036aae1630ffc4111af3
Notes: Anna-Katerina Hadjantonakis verified as MSK author per communication with the author -- Article -- Export Date: 1 June 2021 -- Source: Scopus
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MSK Authors
  1. Joan Massague
    388 Massague
  2. Anna-Katerina Hadjantonakis
    191 Hadjantonakis
  3. Jie Su
    11 Su
  4. Sophie Maria Christina Morgani
    10 Morgani
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