TGF-β in developmental and fibrogenic EMTs Review
| Authors: | Lee, J. H.; Massagué, J. |
| Review Title: | TGF-β in developmental and fibrogenic EMTs |
| Abstract: | TGF-β plays a prominent role as an inducer of epithelial-mesenchymal transitions (EMTs) during development and wound healing and in disease conditions such as fibrosis and cancer. During these processes EMT occurs together with changes in cell proliferation, differentiation, communication, and extracellular matrix remodeling that are orchestrated by multiple signaling inputs besides TGF-β. Chief among these inputs is RAS-MAPK signaling, which is frequently required for EMT induction by TGF-β. Recent work elucidated the molecular basis for the cooperation between the TGF-β-SMAD and RAS-MAPK pathways in the induction of EMT in embryonic, adult and carcinoma epithelial cells. These studies also provided direct mechanistic links between EMT and progenitor cell differentiation during gastrulation or intra-tumoral fibrosis during cancer metastasis. These insights illuminate the nature of TGF-β driven EMTs as part of broader processes during development, fibrogenesis and metastasis. © 2022 The Authors |
| Keywords: | signal transduction; mitogen activated protein kinase; protein expression; unclassified drug; review; binding affinity; cell proliferation; smad protein; smad2 protein; transforming growth factor beta; protein binding; transcription factor; cell differentiation; carcinogenesis; stem cell; extracellular matrix; wound healing; fibrosis; cancer inhibition; dna; epithelium cell; dna sequence; ras protein; development; metastasis potential; cell communication; zinc finger protein; developmental stage; embryo cell; cyclin dependent kinase 1; emt; gastrulation; epithelial mesenchymal transition; smad4 protein; tgf-β; mapk signaling; cancer; human; fibrogenesis; malignant neoplasm; transcription factor foxh1 |
| Journal Title: | Seminars in Cancer Biology |
| Volume: | 86 |
| Issue: | Part 2 |
| ISSN: | 1044-579X |
| Publisher: | Academic Press Inc., Elsevier Science |
| Date Published: | 2022-11-01 |
| Start Page: | 136 |
| End Page: | 145 |
| Language: | English |
| DOI: | 10.1016/j.semcancer.2022.09.004 |
| PUBMED: | 36183999 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Review -- Export Date: 1 November 2022 -- Source: Scopus |
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