Discovery through clinical sequencing in oncology Review
| Authors: | Donoghue, M. T. A.; Schram, A. M.; Hyman, D. M.; Taylor, B. S. |
| Review Title: | Discovery through clinical sequencing in oncology |
| Abstract: | The molecular characterization of tumors now informs clinical cancer care for many patients. This advent of molecular oncology has been driven by the expanding number of therapeutic biomarkers that can predict sensitivity to both approved agents and investigational agents. Beyond its role in driving clinical-trial enrollments and guiding therapy in individual patients, large-scale clinical genomics in oncology also represents a rapidly expanding research resource for translational scientific discovery. Here we review the progress, opportunities, and challenges of scientific and translational discovery from prospective clinical genomic screening programs now routinely conducted for patients with cancer. © 2020, Springer Nature America, Inc. |
| Keywords: | treatment failure; unclassified drug; gene mutation; overall survival; sequence analysis; somatic mutation; gene deletion; review; cancer growth; disease classification; molecular genetics; colorectal cancer; biological marker; gene expression profiling; mitogen activated protein kinase kinase 1; cell infiltration; clinical assessment; gene frequency; genome-wide association study; evolution; chemosensitivity; brca1 protein; brca2 protein; oncology; carcinogenesis; cost effectiveness analysis; health program; health service; myelodysplastic syndrome; algorithm; mismatch repair; microsatellite instability; molecular biology; hla a antigen; hla b antigen; hla c antigen; k ras protein; health care planning; hla antigen; genetic counseling; genetic heterogeneity; copy number variation; isocitrate dehydrogenase 1; genotype phenotype correlation; germline mutation; point of care testing; machine learning; clonal hematopoiesis; human; whole genome sequencing; knowledge discovery; oncogenomics; neoantigen; solid malignant neoplasm; immunogenomics; bioinformatician |
| Journal Title: | Nature Cancer |
| Volume: | 1 |
| Issue: | 8 |
| ISSN: | 2662-1347 |
| Publisher: | Nature Research |
| Date Published: | 2020-08-01 |
| Start Page: | 774 |
| End Page: | 783 |
| Language: | English |
| DOI: | 10.1038/s43018-020-0100-0 |
| PROVIDER: | scopus |
| PUBMED: | 35122052 |
| DOI/URL: | |
| Notes: | Review -- Export Date: 3 May 2021 -- Source: Scopus |
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