Mendelian randomization analysis of n-6 polyunsaturated fatty acid levels and pancreatic cancer risk Journal Article
| Authors: | Ghoneim, D. H.; Zhu, J.; Zheng, W.; Long, J.; Murff, H. J.; Ye, F.; Setiawan, V. W.; Wilkens, L. R.; Khankari, N. K.; Haycock, P.; Antwi, S. O.; Yang, Y.; Arslan, A. A.; Freeman, L. E. B.; Bracci, P. M.; Canzian, F.; Du, M.; Gallinger, S.; Giles, G. G.; Goodman, P. J.; Kooperberg, C.; Le Marchand, L.; Neale, R. E.; Scelo, G.; Visvanathan, K.; White, E.; Albane, D.; Amiano, P.; Andreott, G.; Babic, A.; Bamlet, W. R.; Berndt, S. I.; Brais, L. K.; Brennan, P.; Bueno-De-Mesquita, B.; Buring, J. E.; Campbell, P. T.; Rabe, K. G.; Chanock, S. J.; Duggal, P.; Fuchs, C. S.; Gaziano, J. M.; Goggins, M. G.; Hackert, T.; Hassan, M. M.; Helzlsouer, K. J.; Holly, E. A.; Hoover, R. N.; Katske, V.; Kurtz, R. C.; Lee, I. M.; Malats, N.; Milne, R. L.; Murphy, N.; Oberg, A. L.; Porta, M.; Rothman, N.; Sesso, H. D.; Silverman, D. T.; Thompson, I. M. Jr; Wactawski-Wende, J.; Wang, X.; Wentzensen, N.; Yu, H.; Zeleniuch-Jacquotte, A.; Yu, K.; Wolpin, B. M.; Jacobs, E. J.; Duell, E. J.; Risch, H. A.; Petersen, G. M.; Amundadottir, L. T.; Kraft, P.; Klein, A. P.; Stolzenberg-Solomon, R. Z.; Shu, X. O.; Wu, L. |
| Article Title: | Mendelian randomization analysis of n-6 polyunsaturated fatty acid levels and pancreatic cancer risk |
| Abstract: | Background: Whether circulating polyunsaturated fatty acid (PUFA) levels are associated with pancreatic cancer risk is uncertain. Mendelian randomization (MR) represents a study design using genetic instruments to better characterize the relationship between exposure and outcome. Methods: We utilized data from genome-wide association studies within the Pancreatic Cancer Cohort Consortium and Pancreatic Cancer Case-Control Consortium, involving approximately 9,269 cases and 12,530 controls of European descent, to evaluate associations between pancreatic cancer risk and genetically predicted plasma n-6 PUFA levels. Conventional MR analyses were performed using individual-level and summary-level data. Results: Using genetic instruments, we did not find evidence of associations between genetically predicted plasma n-6 PUFA levels and pancreatic cancer risk [estimates per one SD increase in each PUFA-specific weighted genetic score using summary statistics: Linoleic acid odds ratio (OR)1.00, 95% confidence interval (CI) 0.98-1.02; arachidonic acid OR 1.00, 95% CI 0.99-1.01; and dihomo-gamma-linolenic acid OR 0.95, 95% CI 0.87-1.02]. The OR estimates remained virtually unchanged after adjustment for covariates, using individual-level data or summary statistics, or stratification by age and sex. Conclusions: Our results suggest that variations of genetically determined plasma n-6 PUFA levels are not associated with pancreatic cancer risk. Impact: These results suggest that modifying n-6 PUFA levels through food sources or supplementation may not influence risk of pancreatic cancer. © 2020 American Association for Cancer Research Inc.. All rights reserved. |
| Keywords: | adult; controlled study; aged; major clinical study; cancer risk; pancreas cancer; genome-wide association study; odds ratio; confidence interval; genetic susceptibility; arachidonic acid; nuclear magnetic resonance; linoleic acid; omega 6 fatty acid; polyunsaturated fatty acid; mendelian randomization analysis; human; male; female; priority journal; article; daleuton |
| Journal Title: | Cancer Epidemiology Biomarkers and Prevention |
| Volume: | 29 |
| Issue: | 12 |
| ISSN: | 1055-9965 |
| Publisher: | American Association for Cancer Research |
| Date Published: | 2020-12-01 |
| Start Page: | 2735 |
| End Page: | 2739 |
| Language: | English |
| DOI: | 10.1158/1055-9965.Epi-20-0651 |
| PROVIDER: | scopus |
| PMCID: | PMC7710600 |
| PUBMED: | 32967863 |
| DOI/URL: | |
| Notes: | Article -- Export Date: 3 May 2021 -- Source: Scopus |
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