Adoptive transfer of antigen-specific T-cells of donor type for immunotherapy of viral infections following allogeneic hematopoietic cell transplants Journal Article


Authors: O'Reilly, R. J.; Doubrovina, E.; Trivedi, D.; Hasan, A.; Kollen, W.; Koehne, G.
Article Title: Adoptive transfer of antigen-specific T-cells of donor type for immunotherapy of viral infections following allogeneic hematopoietic cell transplants
Abstract: Allogeneic marrow and cytokine-mobilized peripheral blood stem cells adequately depleted of T cells prevent acute and chronic forms of graft versus host disease in HLA-matched and non-identical hosts without any posttransplant immunosuppressive prophylaxis. Current cytoreductive regimens secure consistent durable engraftment, and full donor chimerism. The risk of relapse following such transplants in patients with AML and ALL has been low, and not different from that recorded following unmodified transplants. However, in HLA-disparate hosts the risk of infections caused by EBV, CMV, and certain fungi are increased. To address this limitation, others and we are exploring adoptive immunotherapies with in vitro generated, pathogen-specific T cells. Early clinical trials already indicate the potential of such T cells to treat and prevent life threatening diseases caused by these pathogens, particularly in recipients of T cell depleted grafts who do not require ongoing treatment with immunosuppressive agents, and therefore provide a permissive environment for the expansion and persistence of the T cells following adoptive transfer. New more predictable strategies are under development, which should allow such therapies to be broadly applicable. © Humana Press Inc. 2007.
Keywords: adult; child; transplantation, homologous; mortality; conference paper; recurrence risk; cytoreductive surgery; t lymphocyte; t-lymphocytes; hematopoietic stem cell transplantation; in vitro study; risk factor; tissue donors; immunotherapy; antigen specificity; acute myeloblastic leukemia; allogeneic hematopoietic stem cell transplantation; adoptive transfer; virus infection; acute lymphocytic leukemia; t cell depletion; graft vs host disease; adoptive immunotherapy; hla antigens; immunosuppressive agent; prevention and control; epstein-barr virus infections; cytomegalovirus infections; transplant-associated infection; prevention study
Journal Title: Immunologic Research
Volume: 38
Issue: 1-3
ISSN: 0257-277X
Publisher: Springer  
Date Published: 2007-01-01
Start Page: 237
End Page: 250
Language: English
DOI: 10.1007/s12026-007-0059-2
PUBMED: 17917029
PROVIDER: scopus
DOI/URL:
Notes: --- - "Cited By (since 1996): 23" - "Export Date: 17 November 2011" - "CODEN: IMRSE" - "Source: Scopus"
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MSK Authors
  1. Wouter Jan Willem Kollen
    7 Kollen
  2. Deepa Trivedi
    14 Trivedi
  3. Guenther Koehne
    194 Koehne
  4. Aisha Nasreen Hasan
    53 Hasan
  5. Richard O'Reilly
    688 O'Reilly