Graft failure after T-cell-depleted human leukocyte antigen identical marrow transplants for leukemia: I. Analysis of risk factors and results of secondary transplants Journal Article

  


Authors: Kernan, N. A.; Bordignon, C.; Heller, G.; Cunningham, I.; Castro-Malaspina, H.; Shank, B.; Flomenberg, N.; Burns, J.; Yang, S. Y.; Black, P.; Collins, N. H.; O'Reilly, R. J.
Article Title: Graft failure after T-cell-depleted human leukocyte antigen identical marrow transplants for leukemia: I. Analysis of risk factors and results of secondary transplants
Abstract: Risk factors for graft failure were analyzed in 122 recipients of an allogeneic T-cell-depleted human leukocyte antigen (HLA)-identical sibling marrow transplant as treatment for leukemia. In each case pretransplant immunosuppression included 1,375 to 1,500 cGy hyperfractionated total body irradiation and cyclophosphamide (60 mg/kg/d x 2). No patient received immunosuppression posttransplant for graft-versus-host disease (GVHD) prophylaxis. Nineteen patients in this group experienced graft failure. The major factors associated with graft failure were transplants from male donors and the age of the patient (or donor). Among male recipients of male donor derived grafts a low dose per kilogram of nucleated cells, progenitor cells (colony forming unit-GM) and T cells was also associated with graft failure. Additional irradiation to 1,500 cGy, high dose corticosteroids posttransplant, and additional peripheral blood donor T cells did not decrease the incidence of graft failure. In addition, type of leukemia, time from diagnosis to transplant, an intact spleen, or the presence of antidonor leukocyte antibodies did not correlate with graft failure. To ensure engraftment of secondary transplants, further immunosuppression was necessary but was poorly tolerated. However, engraftment and survival could be achieved with an immunosuppressive regimen in which antithymocyte globulin and high dose methylprednisolone were administered both before and after infusions of secondary partially T-cell-depleted marrow grafts.
Keywords: adolescent; adult; school child; leukemia; major clinical study; t-lymphocytes; risk factors; cyclophosphamide; age factors; irradiation; graft versus host reaction; methylprednisolone; multivariate analysis; leukocyte count; graft survival; sex factors; immunosuppressive treatment; bone marrow transplantation; leukocyte antigen; oral drug administration; immunosuppression; histocompatibility; antilymphocyte serum; human; male; female; priority journal; support, non-u.s. gov't; support, u.s. gov't, p.h.s.
Journal Title: Blood
Volume: 74
Issue: 6
ISSN: 0006-4971
Publisher: American Society of Hematology  
Date Published: 1989-11-01
Start Page: 2227
End Page: 2236
Language: English
PUBMED: 2804361
PROVIDER: scopus
DOI: 10.1182/blood.V74.6.2227.2227
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-0024427624&partnerID=40&md5=7495a89fc91015bcf8313e4565b3c97e
Notes: Article -- Export Date: 14 April 2020 -- Source: Scopus
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MSK Authors
  1. Soo Y Yang
    108 Yang
  2. Nancy Kernan
    512 Kernan
  3. Glenn Heller
    399 Heller
  4. Hugo Castro-Malaspina
    333 Castro-Malaspina
  5. Richard O'Reilly
    748 O'Reilly
  6. Nancy Collins
    90 Collins
  7. Patricia Black
    31 Black
  8. Neal Flomenberg
    56 Flomenberg
  9. Brenda M. Shank
    45 Shank
  10. Isabel B. Cunningham
    21 Cunningham
  11. Claudio Bordignon
    22 Bordignon
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