T-cell depletion in allogeneic hematopoietic cell transplantation Book Section
| Authors: | Goldberg, J. D.; Perales, M. |
| Editors: | Abutalib, S. A.; Markman, M. |
| Article/Chapter Title: | T-cell depletion in allogeneic hematopoietic cell transplantation |
| Abstract: | Graft-versus-host disease (GVHD) contributes significantly to transplant-related morbidity and mortality (TRM), with an associated mortality rate of 10-25% after hematopoietic cell transplantation (HCT). The risk of grade II-IV acute GVHD in recipients of human leukocyte antigen (HLA)- matched related donor (MRD) and matched unrelated donor (MUD). The use of ex vivo T-cell-depleted (TCD) grafts has significantly reduced the risk of GVHD without the need for posttransplant immunosuppression. This chapter focuses on the use of ex vivo T-cell depletion or CD34 selection of the graft rather than the use of in vivo antibodies such as antithymocyte globulin (ATG) or alemtuzumab. It presents multiple choice questions and answers for T-cell depletion in allogeneic hematopoietic cell transplantation. © 2014 John Wiley and Sons, Inc.. |
| Keywords: | t-cell depletion; human leukocyte antigen (hla); graft-versus-host disease (gvhd); antithymocyte globulin (atg); hematopoietic cell transplantation (hct); matched related donor (mrd); matched unrelated donor (mud) |
| Book Title: | Cancer Consult: Expertise for Clinical Practice |
| ISBN: | 978-1-118-58921-2 |
| Publisher: | Wiley Blackwell |
| Publication Place: | Hoboken, NJ |
| Date Published: | 2014-01-01 |
| Start Page: | 421 |
| End Page: | 425 |
| Language: | English |
| DOI: | 10.1002/9781118589199.ch66 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Book Chapter: 66 -- Export Date: 2 December 2015 -- Source: Scopus |
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