Primary central nervous system lymphoma Journal Article
| Authors: | Mohile, N. A.; Abrey, L. E. |
| Article Title: | Primary central nervous system lymphoma |
| Abstract: | Primary central nervous system lymphoma (PCNSL) is an unusual form of non-Hodgkin's lymphoma that is restricted to the central nervous system. Although it presents with focal neurologic symptoms, it is characterized pathologically by diffuse infiltration of the brain. PCNSL is sensitive to corticosteroids, radiotherapy, and chemotherapy. High-dose methotrexate-based regimens form the cornerstone of multimodality therapy and have significantly improved response rates and survival. Prolonged survival can be associated with devastating neurotoxicity to which the elderly are particularly susceptible. © 2007 Elsevier Inc. All rights reserved. |
| Keywords: | prednisone; clinical feature; review; salvage therapy; multimodality cancer therapy; side effect; combined modality therapy; primary central nervous system lymphoma; cytarabine; methotrexate; nuclear magnetic resonance imaging; combination chemotherapy; vincristine; dose-response relationship, drug; chemosensitivity; carmustine; procarbazine; thiotepa; central nervous system neoplasms; urine incontinence; lymphoma; idarubicin; somnolence; diagnostic test; corticosteroid; acute toxicity; lethargy; ataxia; mental health; brain surgery; teniposide; neurosurgical procedures; behavior change; anti-inflammatory agents; chronic toxicity |
| Journal Title: | Neurologic Clinics |
| Volume: | 25 |
| Issue: | 4 |
| ISSN: | 0733-8619 |
| Publisher: | W.B. Saunders Co-Elsevier Inc. |
| Date Published: | 2007-11-01 |
| Start Page: | 1193 |
| End Page: | 1207 |
| Language: | English |
| DOI: | 10.1016/j.ncl.2007.07.001 |
| PUBMED: | 17964031 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 11" - "Export Date: 17 November 2011" - "CODEN: NECLE" - "Source: Scopus" |
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