Treatment of primary central nervous system lymphoma Journal Article
| Authors: | Shah, G. D.; De Angelis, L. M. |
| Article Title: | Treatment of primary central nervous system lymphoma |
| Abstract: | Primary central nervous system lymphoma (PCNSL) describes a malignant non-Hodgkin's lymphoma (NHL) whose sole site of involvement is the central nervous system (CNS). The diagnosis of PCNSL must be differentiated from systemic NHL with metastasis to the CNS, which usually occurs late in the course of systemic disease. PCNSL accounts for approximately 4% to 7% of primary brain tumors, and its incidence has been increasing since the mid-1970s. Compared with other more common malignant primary brain tumors, PCNSL tends to be more amenable to radiotherapeutic and chemotherapeutic intervention. In this article, the authors review the standard treatment for upfront and recurrent PCNSL. © 2005 Elsevier Inc. All rights reserved. |
| Keywords: | immunohistochemistry; cancer chemotherapy; cancer survival; busulfan; prednisone; clinical trial; drug tolerability; review; cancer recurrence; doxorubicin; side effect; cancer radiotherapy; radiation dose; cytarabine; methotrexate; rituximab; temozolomide; topotecan; drug megadose; neurotoxicity; nuclear magnetic resonance imaging; brain neoplasms; edema; apoptosis; infection; etoposide; cyclophosphamide; dexamethasone; melphalan; vincristine; cytotoxicity; carmustine; ifosfamide; lomustine; procarbazine; thiotepa; central nervous system tumor; pneumonia; gastrointestinal toxicity; insomnia; cancer regression; phenobarbital; topiramate; lymphoma, non-hodgkin; stroke; folinic acid; lymphoma; cancer relapse; methylprednisolone; seizure; drug blood level; dna topoisomerase inhibitor; anticonvulsive agent; corticosteroid; bone marrow transplantation; phenytoin; cytopathology; hematologic disease; valproic acid; myopathy; adrenal insufficiency; weight gain; artery dissection; glucose intolerance |
| Journal Title: | Hematology/Oncology Clinics of North America |
| Volume: | 19 |
| Issue: | 4 |
| ISSN: | 0889-8588 |
| Publisher: | Elsevier Inc. |
| Date Published: | 2005-08-01 |
| Start Page: | 611 |
| End Page: | 627 |
| Language: | English |
| DOI: | 10.1016/j.hoc.2005.05.002 |
| PUBMED: | 16083826 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 13" - "Export Date: 24 October 2012" - "CODEN: HCNAE" - "Source: Scopus" |
