Total synthesis of paecilomycine A Journal Article
| Authors: | Min, S. J.; Danishefsky, S. J. |
| Article Title: | Total synthesis of paecilomycine A |
| Abstract: | (Chemical Equation Presented) Piecing together paecilomycine: The first total synthesis of paecilomycine A, a terpenoid that enhances nerve growth factor levels in certain human cells, has been achieved. Two highly stereoselective key steps in this concise route include an intermolecular Diels-Alder reaction and an intramolecular Pauson-Khand reaction (see scheme). © 2007 Wiley-VCH Verlag GmbH & Co. KGaA. |
| Keywords: | unclassified drug; animal; animals; nerve growth factors; chemistry; rat; chemical structure; molecular structure; rats; plant extract; plant extracts; conformation; diels-alder reaction; diels alder reaction; molecular conformation; degenerative disease; synthesis; total synthesis; synthesis (chemical); neurodegenerative diseases; cells; natural products; cell strain; hydrocarbons; terpenoid; pauson-khand reaction; paecilomyces; reaction kinetics; nerve growth factor; growth kinetics; paecilomycine; pauson khand reaction; paecilomycine a; terpene; pc12 cells; terpenes |
| Journal Title: | Angewandte Chemie - International Edition |
| Volume: | 46 |
| Issue: | 13 |
| ISSN: | 1433-7851 |
| Publisher: | Wiley Blackwell |
| Date Published: | 2007-03-19 |
| Start Page: | 2199 |
| End Page: | 2202 |
| Language: | English |
| DOI: | 10.1002/anie.200605058 |
| PUBMED: | 17300126 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 20" - "Export Date: 17 November 2011" - "CODEN: ACIEA" - "Source: Scopus" |
