Differential cell-intrinsic regulations of germinal center B and T cells by miR-146a and miR-146b Journal Article


Authors: Cho, S.; Lee, H. M.; Yu, I. S.; Choi, Y. S.; Huang, H. Y.; Hashemifar, S. S.; Lin, L. L.; Chen, M. C.; Afanasiev, N. D.; Khan, A. A.; Lin, S. W.; Rudensky, A. Y.; Crotty, S.; Lu, L. F.
Article Title: Differential cell-intrinsic regulations of germinal center B and T cells by miR-146a and miR-146b
Abstract: Reciprocal interactions between B and follicular T helper (Tfh) cells orchestrate the germinal center (GC) reaction, a hallmark of humoral immunity. Abnormal GC responses could lead to the production of pathogenic autoantibodies and the development of autoimmunity. Here we show that miR-146a controls GC responses by targeting multiple CD40 signaling pathway components in B cells; by contrast, loss of miR-146a in T cells does not alter humoral responses. However, specific deletion of both miR-146a and its paralog, miR-146b, in T cells increases Tfh cell numbers and enhanced GC reactions. Thus, our data reveal differential cell-intrinsic regulations of GC B and Tfh cells by miR-146a and miR-146b. Together, members of the miR-146 family serve as crucial molecular brakes to coordinately control GC reactions to generate protective humoral responses without eliciting unwanted autoimmunity. © 2018 The Author(s).
Journal Title: Nature Communications
Volume: 9
ISSN: 2041-1723
Publisher: Nature Publishing Group  
Date Published: 2018-07-01
Start Page: 2757
Language: English
DOI: 10.1038/s41467-018-05196-3
PROVIDER: scopus
PMCID: PMC6048122
PUBMED: 30013024
DOI/URL:
Notes: Article -- Export Date: 4 September 2018 -- Source: Scopus
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  1. Alexander Rudensky
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