Epigenetic dysregulation of myeloproliferative neoplasms Review

   


Authors: Dunbar, A.; Park, Y.; Levine, R.
Review Title: Epigenetic dysregulation of myeloproliferative neoplasms
Abstract: This article reviews the genetic data on epigenetic modifying mutations in myeloproliferative neoplasms and their clinical implications, preclinical studies exploring our current understanding of how mutations in epigenetic modifying proteins cooperate with myeloproliferative neoplasms drivers to promote disease progression, and recent advances in novel therapeutics supporting the role of targeting epigenetic pathways to treat fibrotic progression. © 2021 Elsevier Inc.
Keywords: myelofibrosis; myeloproliferative neoplasms; preclinical studies; epigenetic pathways; epigenetics of mpn; fibrotic progression
Journal Title: Hematology/Oncology Clinics of North America
Volume: 35
Issue: 2
ISSN: 0889-8588
Publisher: Elsevier Inc.  
Date Published: 2021-04-01
Start Page: 237
End Page: 251
Language: English
DOI: 10.1016/j.hoc.2021.01.001
PUBMED: 33641866
PROVIDER: scopus
PMCID: PMC7927771
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-85100436403&doi=10.1016%2fj.hoc.2021.01.001&partnerID=40&md5=9d5b65158b0fa4cc0b3310c9fc5aff15
Notes: Review -- Export Date: 1 April 2021 -- Source: Scopus
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MSK Authors
  1. Ross Levine
    775 Levine
  2. Andrew Jeffrey Dunbar
    44 Dunbar
  3. Young Park
    16 Park
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