The role of mutations in epigenetic regulators in myeloid malignancies Journal Article
| Authors: | Woods, B. A.; Levine, R. L. |
| Article Title: | The role of mutations in epigenetic regulators in myeloid malignancies |
| Abstract: | Summary: Over the past decade, genomic studies have identified a number of novel and recurrent somatic mutations that affect epigenetic patterning in patients with myeloid malignancies, including myeloproliferative neoplasms, myelodysplastic syndrome, and acute myeloid leukemia. Many of these mutations occur in genes with established roles in the regulation and maintenance of DNA methylation and/or chromatin modifications in hematopoietic stem/progenitor cells. Subsequent genetic and functional studies have revealed that these mutations affect epigenetic patterning in myeloid diseases. In this review, we discuss historical and recent studies implicating epigenetic modifiers in the development and evolution of the various myeloid malignancies and discuss how this knowledge has and will lead to future clinical and biologic insights. © 2015 John Wiley & Sons A/S. |
| Keywords: | cancer survival; unclassified drug; chronic myelomonocytic leukemia; gene mutation; overall survival; somatic mutation; missense mutation; histone deacetylase inhibitor; nonhuman; cohesin; gene expression; protein; cytogenetics; dna methylation; hematologic malignancy; myelodysplastic syndrome; dna modification; epigenetics; heterozygosity; acute myeloblastic leukemia; genomics; gene control; hematopoiesis; large cell lymphoma; spliceosome; genome imprinting; dna methyltransferase 1; myeloproliferative neoplasm; dna methyltransferase 3b; leukemia remission; transcription elongation; dna methyltransferase 3a; transcription factor ezh2; cd135 antigen; nucleophosmin; histone modification; dna methyltransferase inhibitor; chromatin regulation; myelopoiesis; histone acetylation; human; priority journal; article; additional sex combs like 1 |
| Journal Title: | Immunological Reviews |
| Volume: | 263 |
| Issue: | 1 |
| ISSN: | 0105-2896 |
| Publisher: | Wiley Blackwell |
| Date Published: | 2015-01-01 |
| Start Page: | 22 |
| End Page: | 35 |
| Language: | English |
| DOI: | 10.1111/imr.12246 |
| PROVIDER: | scopus |
| PUBMED: | 25510269 |
| DOI/URL: | |
| Notes: | Export Date: 2 July 2015 -- Source: Scopus |
Altmetric
Citation Impact
BMJ Impact Analytics
Related MSK Work