EZH2 mutations: Mutating the epigenetic machinery in myeloid malignancies Journal Article

  


Authors: Abdel-Wahab, O.; Levine, R. L.
Article Title: EZH2 mutations: Mutating the epigenetic machinery in myeloid malignancies
Abstract: Two recent studies identified loss-of-function mutations in the histone H3 methyltransferase EZH2 in myelodysplastic syndromes and myeloproliferative neoplasms, provided further demonstration of mutations in epigenetic modifiers in myeloid malignancies, and suggest EZH2 functions as a tumor-suppressor gene in these malignancies rather than an oncogene as in some other malignancies. © 2010 Elsevier Inc.
Keywords: gene mutation; somatic mutation; pathogenesis; nonhuman; gene overexpression; dna methylation; gene expression regulation; oncogene; tumor suppressor gene; methyltransferase; hematologic malignancy; myelodysplastic syndrome; epigenetics; histone h3; short survey; chromosome translocation; gene inactivation; malignant transformation; ezh2 gene
Journal Title: Cancer Cell
Volume: 18
Issue: 2
ISSN: 1535-6108
Publisher: Cell Press  
Date Published: 2010-08-17
Start Page: 105
End Page: 107
Language: English
DOI: 10.1016/j.ccr.2010.07.006
PROVIDER: scopus
DOI/URL:

http://www.scopus.com/inward/record.url?eid=2-s2.0-77955542914&partnerID=40&md5=e0c4db1c958190075a9f9f4582d47fc9
Notes: --- - "Export Date: 20 April 2011" - "CODEN: CCAEC" - "Source: Scopus"
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MSK Authors
  1. Ross Levine
    786 Levine
  2. Omar Ibrahim Abdel-Wahab
    585 Abdel-Wahab
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