Nongaussian intravoxel incoherent motion diffusion weighted and fast exchange regime dynamic contrast-enhanced-MRI of nasopharyngeal carcinoma: Preliminary study for predicting locoregional failure Journal Article
| Authors: | Paudyal, R.; Chen, L.; Oh, J. H.; Zakeri, K.; Hatzoglou, V.; Tsai, C. J.; Lee, N.; Shukla-Dave, A. |
| Article Title: | Nongaussian intravoxel incoherent motion diffusion weighted and fast exchange regime dynamic contrast-enhanced-MRI of nasopharyngeal carcinoma: Preliminary study for predicting locoregional failure |
| Abstract: | The aim of the present study was to identify whether the quantitative metrics from pre-treatment (TX) non-Gaussian intravoxel incoherent motion (NGIVIM) diffusion weighted (DW-) and fast exchange regime (FXR) dynamic contrast enhanced (DCE)-MRI can predict patients with locoregional failure (LRF) in nasopharyngeal carcinoma (NPC). Twenty-nine NPC patients under-went pre-TX DW-and DCE-MRI on a 3T MR scanner. DW imaging data from primary tumors were fitted to monoexponential (ADC) and NGIVIM (D, D*, f, and K) models. The metrics Ktrans, ve, and τi were estimated using the FXR model. Cumulative incidence (CI) analysis and Fine-Gray (FG) modeling were performed considering death as a competing risk. Mean ve values were signifi-cantly different between patients with and without LRF (p = 0.03). Mean f values showed a trend towards the difference between the groups (p = 0.08). Histograms exhibited inter primary tumor heterogeneity. The CI curves showed significant differences for the dichotomized cutoff value of ADC ≤ 0.68 × 10−3 (mm2/s), D ≤ 0.74 × 10−3 (mm2/s), and f ≤ 0.18 (p < 0.05). τi ≤ 0.89 (s) cutoff value showed borderline significance (p = 0.098). FG’s modeling showed a significant difference for the K cutoff value of ≤0.86 (p = 0.034). Results suggest that the role of pre-TX NGIVIM DW-and FXR DCE-MRI-derived metrics for predicting LRF in NPC than alone. © 2021 by the authors. Licensee MDPI, Basel, Switzerland. |
| Keywords: | permeability; dynamic contrast-enhanced; metabolic activity; gaussian and non-gaussian; diffusion weighted; fast exchange regime; kurtosis |
| Journal Title: | Cancers |
| Volume: | 13 |
| Issue: | 5 |
| ISSN: | 2072-6694 |
| Publisher: | MDPI |
| Date Published: | 2021-03-01 |
| Start Page: | 1128 |
| Language: | English |
| DOI: | 10.3390/cancers13051128 |
| PROVIDER: | scopus |
| PMCID: | PMC7961986 |
| PUBMED: | 33800762 |
| DOI/URL: | |
| Notes: | Article -- Export Date: 1 April 2021 -- Source: Scopus |
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