Chemotherapy in the elderly Journal Article
| Author: | Lichtman, S. M. |
| Article Title: | Chemotherapy in the elderly |
| Abstract: | People over the age of 65 years constitute the fastest-growing segment of the US population. Within the next 30 years, this group will comprise over 20% of the total population. Importantly, 50% of all cancers and 70% of cancer mortality occur in this age group. Choosing the correct chemotherapy regimen and dose for the older patient can be extremely difficult due to physiological changes that occur with aging, as well as other comorbidities associated with this age group. Treatment decisions need to be based on a patient's individual performance, functional status, life expectancy, and their wishes and opinions. Although there are no accepted algorithms to guide management decisions in elderly cancer patients, data are becoming available that will help guide the use of chemotherapy in the older patient population. © 2007 Future Medicine Ltd. |
| Keywords: | cancer chemotherapy; cancer survival; overall survival; fludarabine; prednisone; clinical trial; neutropenia; review; cisplatin; doxorubicin; monotherapy; nonhuman; gemcitabine; adjuvant therapy; disease free survival; pancreas cancer; chemotherapy; cytarabine; methotrexate; rituximab; lymph node metastasis; antineoplastic agent; cancer incidence; nutritional status; carboplatin; dacarbazine; quality of life; breast cancer; anemia; lung non small cell cancer; creatinine; cyclophosphamide; melphalan; vincristine; practice guideline; cancer mortality; carmustine; ifosfamide; prostate cancer; social support; depression; nonhodgkin lymphoma; health status; drug distribution; blood sampling; colon cancer; mitoxantrone; comorbidity; bleomycin; glomerulus filtration rate; hematopoiesis; aging; clinical decision making; cognitive defect; daily life activity; drug metabolism; drug absorption; platinum complex; taxane derivative; anthracycline; growth factor; elderly care; frail elderly; elderly; life expectancy; mental health; dose calculation; functional status; drug excretion; clinical trials; pharmacokinetics; polypharmacy; creatinine clearance; geriatric assessment; function; assessment; cytochrome p450 3a4; kidney dysfunction; epipodophyllotoxin derivative; frailty; home environment |
| Journal Title: | Aging Health |
| Volume: | 3 |
| Issue: | 2 |
| ISSN: | 1745-509X |
| Publisher: | Future Medicine |
| Date Published: | 2007-04-01 |
| Start Page: | 165 |
| End Page: | 175 |
| Language: | English |
| DOI: | 10.2217/1745509x.3.2.165 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 2" - "Export Date: 17 November 2011" - "Source: Scopus" |
