Clinical pharmacology issues relevant to the dosing and toxicity of chemotherapy drugs in the elderly Journal Article
| Authors: | Wasil, T.; Lichtman, S. M. |
| Article Title: | Clinical pharmacology issues relevant to the dosing and toxicity of chemotherapy drugs in the elderly |
| Abstract: | Persons over the age of 65 years are the fastest growing segment of the U.S. population. In the next 30 years, they will comprise more than 20% of the population. Fifty percent of all cancers occur in this age group, and therefore, there is an expected rise in the total cancer burden. Data are becoming available that will better guide the use of chemotherapy in the older patient population. In this paper, information regarding age-related physiologic changes and their relationship to pharmacology, functional status, and hematopoiesis is presented. The adjuvant treatment of breast and colon cancer, as well as the primary therapy of aggressive non-Hodgkin lymphoma is reviewed. The treatment of more advanced breast, ovarian, and non-small cell lung cancer is also discussed. ©AlphaMed Press. |
| Keywords: | aged; aged, 80 and over; functional assessment; osteolysis; prednisone; neutropenia; review; bevacizumab; cisplatin; doxorubicin; fluorouracil; advanced cancer; cancer combination chemotherapy; diarrhea; side effect; antineoplastic agents; capecitabine; gemcitabine; paclitaxel; chemotherapy; rituximab; topotecan; neurotoxicity; antineoplastic agent; neoplasms; imatinib; carboplatin; nephrotoxicity; ovary cancer; breast cancer; bone marrow suppression; etoposide; allergy; leukopenia; lung non small cell cancer; mucosa inflammation; nausea; vomiting; peripheral neuropathy; cyclophosphamide; vincristine; cetuximab; high risk patient; docetaxel; exemestane; irinotecan; drug hypersensitivity; rash; systematic review; early diagnosis; folinic acid; cardiotoxicity; acne; comorbidity; gefitinib; hematopoiesis; aging; letrozole; drug metabolism; drug absorption; high risk population; drug half life; toxicity; trastuzumab; anastrozole; navelbine; oxaliplatin; granulocyte colony stimulating factor; pemetrexed; elderly; amifostine; pharmacology; geriatrics; fulvestrant; ototoxicity; cytochrome p450 3a4; tamoxifen citrate; dose kidney function relation |
| Journal Title: | The Oncologist |
| Volume: | 10 |
| Issue: | 8 |
| ISSN: | 1083-7159 |
| Publisher: | Oxford University Press |
| Date Published: | 2005-09-01 |
| Start Page: | 602 |
| End Page: | 612 |
| Language: | English |
| DOI: | 10.1634/theoncologist.10-8-602 |
| PUBMED: | 16177284 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 32" - "Export Date: 24 October 2012" - "CODEN: OCOLF" - "Source: Scopus" |
